Detailed information of TA system TA075848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 58468..59135
• Replicon: plasmid pA
• Accession: NZ_CP020976
• Organism: Xanthomonas phaseoli pv. phaseoli strain CFBP6982

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3T0G501
• Locus tag: XppCFBP6982P_RS23375
• Protein ID: WP_022557732.1
• Coordinates: 58719..59135 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U4M4Z6
• Locus tag: XppCFBP6982P_RS23370
• Protein ID: WP_022557731.1
• Coordinates: 58468..58722 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XppCFBP6982P_RS23350	53932..54276	-	345	WP_039572167.1	hypothetical protein	-
XppCFBP6982P_RS23355	54374..54604	-	231	Protein_57	hypothetical protein	-
XppCFBP6982P_RS23360	54637..57666	-	3030	WP_022560486.1	Tn3 family transposase	-
XppCFBP6982P_RS23365	57663..58256	-	594	WP_022560487.1	recombinase family protein	-
XppCFBP6982P_RS23370	58468..58722	+	255	WP_022557731.1	plasmid stability protein	Antitoxin
XppCFBP6982P_RS23375	58719..59135	+	417	WP_022557732.1	type II toxin-antitoxin system VapC family toxin	Toxin
XppCFBP6982P_RS23380	59149..59703	+	555	WP_033482006.1	plasmid pRiA4b ORF-3 family protein	-
XppCFBP6982P_RS23385	59784..60149	-	366	Protein_63	hypothetical protein	-
XppCFBP6982P_RS23390	60163..60402	-	240	WP_039572160.1	hypothetical protein	-
XppCFBP6982P_RS24505	60399..60560	-	162	WP_157926053.1	hypothetical protein	-
XppCFBP6982P_RS23395	60633..61031	-	399	WP_039572158.1	hypothetical protein	-
XppCFBP6982P_RS24510	61387..61677	-	291	WP_127446651.1	hypothetical protein	-
XppCFBP6982P_RS23400	61698..61973	-	276	WP_039572155.1	hypothetical protein	-
XppCFBP6982P_RS23405	62377..62700	-	324	WP_039572152.1	hypothetical protein	-
XppCFBP6982P_RS23420	63357..63551	+	195	WP_080948835.1	ribbon-helix-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	virB1 / virB1	1..78818	78818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14833.04 Da
• Isoelectric Point: 4.6812

>T75848 WP_022557732.1 NZ_CP020976:58719-59135 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Nucleotide

• Length: 417 bp

>T75848 NZ_CP020976:58719-59135 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9388.80 Da
• Isoelectric Point: 8.9326

>AT75848 WP_022557731.1 NZ_CP020976:58468-58722 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Nucleotide

• Length: 255 bp

>AT75848 NZ_CP020976:58468-58722 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A3T0G501

Antitoxin

• AlphaFold DB: A0A3T0G545