Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 27267..27934 Replicon plasmid pC
Accession NZ_CP020973
Organism Xanthomonas phaseoli pv. phaseoli strain CFBP6546R

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XppCFBP6546P_RS22305 Protein ID WP_022557732.1
Coordinates 27267..27683 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XppCFBP6546P_RS22310 Protein ID WP_022557731.1
Coordinates 27680..27934 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XppCFBP6546P_RS22740 22847..25351 + 2505 WP_236493581.1 type III secretion system effector protein XopC -
XppCFBP6546P_RS22295 (XppCFBP6546P_23420) 25904..26605 - 702 Protein_26 IS3-like element ISXac2 family transposase -
XppCFBP6546P_RS22300 (XppCFBP6546P_23425) 26699..27253 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XppCFBP6546P_RS22305 (XppCFBP6546P_23430) 27267..27683 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XppCFBP6546P_RS22310 (XppCFBP6546P_23435) 27680..27934 - 255 WP_022557731.1 plasmid stability protein Antitoxin
XppCFBP6546P_RS22315 (XppCFBP6546P_23440) 28146..28739 + 594 WP_022560487.1 recombinase family protein -
XppCFBP6546P_RS22320 (XppCFBP6546P_23445) 28736..31765 + 3030 WP_022560486.1 Tn3 family transposase -
XppCFBP6546P_RS22325 (XppCFBP6546P_23450) 31797..32173 - 377 Protein_32 transposase -
XppCFBP6546P_RS22330 (XppCFBP6546P_23460) 32425..32745 + 321 WP_033481941.1 ParC family partition-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..52530 52530
- inside IScluster/Tn - - 17886..37642 19756


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T75845 WP_022557732.1 NZ_CP020973:c27683-27267 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T75845 NZ_CP020973:c27683-27267 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT75845 WP_022557731.1 NZ_CP020973:c27934-27680 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT75845 NZ_CP020973:c27934-27680 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References