Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 17430..18097 Replicon plasmid pC
Accession NZ_CP020969
Organism Xanthomonas phaseoli pv. phaseoli strain CFBP6164

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XppCFBP6164P_RS24590 Protein ID WP_022557732.1
Coordinates 17681..18097 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XppCFBP6164P_RS24585 Protein ID WP_022557731.1
Coordinates 17430..17684 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XppCFBP6164P_RS24560 12619..12939 - 321 WP_033481941.1 hypothetical protein -
XppCFBP6164P_RS24570 13191..13567 + 377 Protein_11 transposase -
XppCFBP6164P_RS24575 13599..16628 - 3030 WP_022560486.1 Tn3 family transposase -
XppCFBP6164P_RS24580 16625..17218 - 594 WP_022560487.1 recombinase family protein -
XppCFBP6164P_RS24585 17430..17684 + 255 WP_022557731.1 plasmid stability protein Antitoxin
XppCFBP6164P_RS24590 17681..18097 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XppCFBP6164P_RS24595 18111..18665 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XppCFBP6164P_RS24600 18759..19460 + 702 Protein_17 IS3 family transposase -
XppCFBP6164P_RS24610 20013..21560 - 1548 WP_080720984.1 HAD hydrolase-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56017 56017
- inside IScluster/Tn - - 7722..31827 24105


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T75841 WP_022557732.1 NZ_CP020969:17681-18097 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T75841 NZ_CP020969:17681-18097 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT75841 WP_022557731.1 NZ_CP020969:17430-17684 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT75841 NZ_CP020969:17430-17684 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References