Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 41768..42435 Replicon plasmid pA
Accession NZ_CP020968
Organism Xanthomonas phaseoli pv. phaseoli strain CFBP6164

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XppCFBP6164P_RS24290 Protein ID WP_022557732.1
Coordinates 41768..42184 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XppCFBP6164P_RS24295 Protein ID WP_022557731.1
Coordinates 42181..42435 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XppCFBP6164P_RS24265 37498..38817 + 1320 WP_022557736.1 DUF4990 domain-containing protein -
XppCFBP6164P_RS24270 38944..40236 + 1293 WP_033481893.1 hypothetical protein -
XppCFBP6164P_RS24275 40388..40918 + 531 Protein_47 DNA topoisomerase III -
XppCFBP6164P_RS24280 40988..41125 + 138 Protein_48 transposase -
XppCFBP6164P_RS24285 41200..41754 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XppCFBP6164P_RS24290 41768..42184 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XppCFBP6164P_RS24295 42181..42435 - 255 WP_022557731.1 plasmid stability protein Antitoxin
XppCFBP6164P_RS24300 42647..43240 + 594 WP_022560487.1 recombinase family protein -
XppCFBP6164P_RS24305 43237..46266 + 3030 WP_022560486.1 Tn3 family transposase -
XppCFBP6164P_RS25615 46299..46684 + 386 Protein_54 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..70765 70765
- inside IScluster/Tn - virB1 40988..58565 17577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T75840 WP_022557732.1 NZ_CP020968:c42184-41768 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T75840 NZ_CP020968:c42184-41768 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT75840 WP_022557731.1 NZ_CP020968:c42435-42181 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT75840 NZ_CP020968:c42435-42181 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References