75826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2290228..2290742 Replicon chromosome
Accession NZ_CP020960
Organism Staphylococcus aureus strain JK3137

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag B9T46_RS12225 Protein ID WP_000581792.1
Coordinates 2290228..2290437 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag B9T46_RS12230 Protein ID WP_000138932.1
Coordinates 2290449..2290742 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T46_RS12205 2285736..2287094 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
B9T46_RS12210 2287109..2288179 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
B9T46_RS12215 2288497..2289699 + 1203 WP_001109939.1 rod shape-determining protein RodA -
B9T46_RS12220 2289963..2290100 - 138 WP_000828354.1 hypothetical protein -
B9T46_RS12225 2290228..2290437 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
B9T46_RS12230 2290449..2290742 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
B9T46_RS12235 2290908..2292392 + 1485 WP_000571549.1 cardiolipin synthase -
B9T46_RS12240 2292420..2293067 + 648 WP_001187629.1 HD domain-containing protein -
B9T46_RS12265 2293880..2294752 - 873 WP_000725802.1 membrane protein insertase YidC -
B9T46_RS12270 2294838..2295479 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T75826 WP_000581792.1 NZ_CP020960:c2290437-2290228 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T75826 NZ_CP020960:c2290437-2290228 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT75826 WP_000138932.1 NZ_CP020960:c2290742-2290449 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT75826 NZ_CP020960:c2290742-2290449 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References