Detailed information of TA system TA075821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1024962..1025759
• Replicon: chromosome
• Accession: NZ_CP020960
• Organism: Staphylococcus aureus strain JK3137

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: B9T46_RS05395
• Protein ID: WP_000525008.1
• Coordinates: 1024962..1025423 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: B9T46_RS05400
• Protein ID: WP_001260487.1
• Coordinates: 1025436..1025759 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T46_RS05370	1020698..1021228	+	531	WP_000184383.1	acyl-CoA thioesterase	-
B9T46_RS05375	1021488..1022633	-	1146	WP_001245448.1	radical SAM/CxCxxxxC motif protein YfkAB	-
B9T46_RS05380	1022678..1023724	-	1047	WP_001145732.1	site-specific integrase	-
B9T46_RS05385	1023794..1024264	-	471	WP_000183249.1	hypothetical protein	-
B9T46_RS05390	1024257..1024778	-	522	WP_001102444.1	hypothetical protein	-
B9T46_RS05395	1024962..1025423	-	462	WP_000525008.1	hypothetical protein	Toxin
B9T46_RS05400	1025436..1025759	-	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
B9T46_RS05405	1025922..1026170	+	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
B9T46_RS05410	1026183..1026626	+	444	WP_000435356.1	hypothetical protein	-
B9T46_RS05415	1026641..1026820	+	180	WP_000393082.1	hypothetical protein	-
B9T46_RS05420	1026810..1027049	-	240	WP_000438628.1	hypothetical protein	-
B9T46_RS05425	1027106..1027897	+	792	WP_001157019.1	phage antirepressor KilAC domain-containing protein	-
B9T46_RS05430	1027898..1028122	+	225	WP_000187184.1	hypothetical protein	-
B9T46_RS05435	1028162..1028611	+	450	WP_000993183.1	hypothetical protein	-
B9T46_RS05440	1028625..1028855	+	231	WP_000977379.1	hypothetical protein	-
B9T46_RS05445	1028839..1029000	+	162	WP_000066005.1	DUF1270 family protein	-
B9T46_RS05450	1029092..1029352	+	261	WP_000291068.1	DUF1108 family protein	-
B9T46_RS05455	1029362..1029583	+	222	WP_000815401.1	DUF2483 family protein	-
B9T46_RS05460	1029576..1030364	+	789	WP_000134097.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1022678..1064264	41586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18034.35 Da
• Isoelectric Point: 4.6899

>T75821 WP_000525008.1 NZ_CP020960:c1025423-1024962 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T75821 NZ_CP020960:c1025423-1024962 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTTGAAGCGCACAATTACGGTGTACGTAATTTATATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT75821 WP_001260487.1 NZ_CP020960:c1025759-1025436 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT75821 NZ_CP020960:c1025759-1025436 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36