75805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 871969..872446 Replicon chromosome
Accession NZ_CP020959
Organism Staphylococcus aureus strain H489

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag B9T45_RS04530 Protein ID WP_000052078.1
Coordinates 871969..872157 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B9T45_RS04535 Protein ID WP_001059690.1
Coordinates 872186..872446 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T45_RS04500 868010..868480 + 471 WP_000824472.1 hypothetical protein -
B9T45_RS04505 868821..869507 + 687 WP_001548082.1 thermonuclease family protein -
B9T45_RS04510 869864..870064 + 201 WP_001059082.1 cold-shock protein -
B9T45_RS04515 870560..870778 - 219 WP_000005886.1 hypothetical protein -
B9T45_RS04520 870840..871124 - 285 WP_001004395.1 hypothetical protein -
B9T45_RS04525 871212..871781 - 570 WP_001106654.1 hypothetical protein -
B9T45_RS04530 871969..872157 - 189 WP_000052078.1 hypothetical protein Toxin
B9T45_RS04535 872186..872446 - 261 WP_001059690.1 hypothetical protein Antitoxin
B9T45_RS04540 872787..872990 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B9T45_RS04545 872987..873223 - 237 WP_000368687.1 hypothetical protein -
B9T45_RS04550 873448..874029 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
B9T45_RS04555 874102..874719 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
B9T45_RS04560 874874..875368 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
B9T45_RS04565 875767..876189 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B9T45_RS04570 876337..877053 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 840693..882932 42239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T75805 WP_000052078.1 NZ_CP020959:c872157-871969 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75805 NZ_CP020959:c872157-871969 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75805 WP_001059690.1 NZ_CP020959:c872446-872186 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75805 NZ_CP020959:c872446-872186 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References