Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 820333..820810 Replicon chromosome
Accession NZ_CP020957
Organism Staphylococcus aureus strain C3948

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag B9T42_RS04105 Protein ID WP_000052078.1
Coordinates 820333..820521 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B9T42_RS04110 Protein ID WP_001059690.1
Coordinates 820550..820810 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T42_RS04075 816374..816844 + 471 WP_000824472.1 hypothetical protein -
B9T42_RS04080 817185..817871 + 687 WP_001548082.1 thermonuclease family protein -
B9T42_RS04085 818228..818428 + 201 WP_001059082.1 cold-shock protein -
B9T42_RS04090 818924..819142 - 219 WP_000005886.1 hypothetical protein -
B9T42_RS04095 819204..819488 - 285 WP_001004395.1 hypothetical protein -
B9T42_RS04100 819576..820145 - 570 WP_001106654.1 hypothetical protein -
B9T42_RS04105 820333..820521 - 189 WP_000052078.1 hypothetical protein Toxin
B9T42_RS04110 820550..820810 - 261 WP_001059690.1 hypothetical protein Antitoxin
B9T42_RS04115 821151..821354 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B9T42_RS04120 821351..821587 - 237 WP_000368687.1 hypothetical protein -
B9T42_RS04125 821812..822393 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
B9T42_RS04130 822466..823083 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
B9T42_RS04135 823238..823732 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
B9T42_RS04140 824131..824553 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B9T42_RS04145 824701..825417 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T75785 WP_000052078.1 NZ_CP020957:c820521-820333 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T75785 NZ_CP020957:c820521-820333 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT75785 WP_001059690.1 NZ_CP020957:c820810-820550 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT75785 NZ_CP020957:c820810-820550 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References