75767

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 898853..899660 Replicon chromosome
Accession NZ_CP020953
Organism Clostridium drakei strain SL1

Toxin (Protein)


Gene name hepT Uniprot ID A0A2U8DNA9
Locus tag B9W14_RS04135 Protein ID WP_032076671.1
Coordinates 899256..899660 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A2U8DLY5
Locus tag B9W14_RS04130 Protein ID WP_032076672.1
Coordinates 898853..899263 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9W14_RS04105 894867..895883 + 1017 WP_032076675.1 SDR family NAD(P)-dependent oxidoreductase -
B9W14_RS04110 895917..896975 + 1059 WP_032076674.1 UDP-2,4-diacetamido-2,4, 6-trideoxy-beta-L-altropyranose hydrolase -
B9W14_RS04115 897025..898032 + 1008 WP_032076673.1 SDR family NAD(P)-dependent oxidoreductase -
B9W14_RS04120 898236..898466 + 231 WP_052037775.1 hypothetical protein -
B9W14_RS04125 898550..898717 + 168 WP_084572181.1 YjfB family protein -
B9W14_RS04130 898853..899263 + 411 WP_032076672.1 nucleotidyltransferase domain-containing protein Antitoxin
B9W14_RS04135 899256..899660 + 405 WP_032076671.1 DUF86 domain-containing protein Toxin
B9W14_RS04140 899965..900297 - 333 WP_032076670.1 single-stranded DNA-binding protein -
B9W14_RS04145 900664..901002 + 339 WP_032076669.1 hypothetical protein -
B9W14_RS04150 901188..903929 + 2742 WP_032076668.1 cell wall-binding repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(13-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(10-100)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15697.35 Da        Isoelectric Point: 6.7155

>T75767 WP_032076671.1 NZ_CP020953:899256-899660 [Clostridium drakei]
MSKDVILNKISVIERCIKRINEEYENNFENLKNYTKQDSIILNIQRACEASIDLAMHIVSEKKLGIPQNSRDAFEVLYSN
NIIDEKLMKNLKAMVGFRNIAVHDYQAVNLEIVKQIIEKHLLELKEFVQLMLYI

Download         Length: 405 bp

>T75767 NZ_CP020953:899256-899660 [Clostridium drakei]
ATGAGTAAAGATGTTATACTGAATAAAATATCAGTTATAGAAAGATGCATAAAGAGGATAAATGAAGAGTATGAAAATAA
TTTTGAGAACCTAAAGAATTATACAAAACAGGATTCTATAATTTTAAATATACAAAGAGCTTGTGAAGCATCTATAGATT
TAGCAATGCACATTGTTTCTGAAAAAAAACTTGGAATTCCGCAAAATAGCAGAGATGCTTTTGAAGTGCTTTATAGTAAC
AACATTATAGATGAAAAACTTATGAAAAATTTGAAGGCTATGGTTGGATTTAGGAACATAGCAGTTCATGATTATCAAGC
TGTAAATTTAGAAATAGTGAAGCAAATAATTGAAAAGCATTTGTTAGAGTTGAAGGAATTTGTTCAACTGATGCTTTATA
TATAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 16008.54 Da        Isoelectric Point: 5.0099

>AT75767 WP_032076672.1 NZ_CP020953:898853-899263 [Clostridium drakei]
MKQNLNINIEKITDFLVENIKPYLIYLFGSSVNGVFREDSDIDIAFMSDKKITEYEVFMLAQELADILKRDVDLINLKNA
STVFKAQIVGKGKVIYCSDDKRRMYFEMYVFKDYALLNEEREIILNSIKQRGHIYE

Download         Length: 411 bp

>AT75767 NZ_CP020953:898853-899263 [Clostridium drakei]
ATGAAACAGAATTTAAATATTAATATAGAAAAAATAACTGATTTTCTTGTTGAAAACATTAAGCCTTATTTAATATATTT
ATTTGGTTCAAGTGTAAATGGAGTTTTTAGAGAAGATAGTGATATAGATATTGCTTTTATGAGTGATAAAAAAATTACTG
AATATGAAGTTTTTATGCTAGCACAGGAATTAGCAGATATACTAAAACGAGATGTAGATTTGATTAACTTAAAAAATGCA
TCTACAGTATTTAAGGCACAGATAGTGGGAAAAGGAAAAGTAATATATTGTTCAGATGATAAAAGAAGAATGTATTTTGA
AATGTATGTGTTTAAAGATTATGCTTTATTAAATGAGGAAAGGGAGATAATTTTAAATAGTATAAAGCAGAGGGGGCATA
TATATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U8DNA9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U8DLY5

References