Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 92474..93009 Replicon plasmid pRheCIAT894a
Accession NZ_CP020948
Organism Rhizobium sp. CIAT894

Toxin (Protein)


Gene name parE Uniprot ID A0A1S1PXS8
Locus tag RHEC894_RS22130 Protein ID WP_010064973.1
Coordinates 92719..93009 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID B6A4M1
Locus tag RHEC894_RS22125 Protein ID WP_012559996.1
Coordinates 92474..92722 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RHEC894_RS22110 88069..89772 + 1704 WP_085739158.1 ABC transporter ATP-binding protein -
RHEC894_RS22115 89792..91306 + 1515 WP_085739159.1 ABC transporter substrate-binding protein -
RHEC894_RS22120 91387..92262 - 876 WP_085739160.1 glutathione-dependent disulfide-bond oxidoreductase -
RHEC894_RS22125 92474..92722 + 249 WP_012559996.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
RHEC894_RS22130 92719..93009 + 291 WP_010064973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RHEC894_RS22135 93157..94236 - 1080 WP_085739161.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
RHEC894_RS22140 94258..94638 - 381 WP_085739162.1 cupin domain-containing protein -
RHEC894_RS22145 94654..95745 - 1092 WP_085739163.1 Gfo/Idh/MocA family oxidoreductase -
RHEC894_RS22150 95748..96575 - 828 WP_085739164.1 carbohydrate ABC transporter permease -
RHEC894_RS22155 96572..97567 - 996 WP_085739165.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..215247 215247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11054.56 Da        Isoelectric Point: 8.0703

>T75762 WP_010064973.1 NZ_CP020948:92719-93009 [Rhizobium sp. CIAT894]
MTGIIFSPAAQTDIDKIWDYTATSWNVDQAERYIQDIRDACHELAEGTRMSRPSDIRKGYRKVSVGSHFLYFKSNDAGQI
IVVRILHQRMDVAKHL

Download         Length: 291 bp

>T75762 NZ_CP020948:92719-93009 [Rhizobium sp. CIAT894]
ATGACAGGCATCATATTTTCCCCCGCCGCGCAAACCGATATTGACAAGATTTGGGATTACACAGCGACGAGTTGGAATGT
CGATCAGGCAGAGCGTTACATTCAGGACATAAGAGACGCCTGTCACGAACTGGCGGAGGGAACACGGATGAGCCGTCCCT
CAGACATTCGGAAAGGGTACAGAAAGGTCTCCGTTGGCTCGCATTTTCTGTATTTCAAAAGTAATGATGCGGGCCAGATC
ATCGTTGTACGCATCCTTCATCAAAGAATGGATGTAGCCAAGCACTTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9001.02 Da        Isoelectric Point: 5.0760

>AT75762 WP_012559996.1 NZ_CP020948:92474-92722 [Rhizobium sp. CIAT894]
MARNTSISLSDHFVSFIDTQVQAGRYGSATDVVRAGLRLLEEHEAKVKALQDALIEGEESGPATPFDFDAFNARKRATFE
AK

Download         Length: 249 bp

>AT75762 NZ_CP020948:92474-92722 [Rhizobium sp. CIAT894]
ATGGCTAGAAATACGTCCATATCGCTCAGCGACCATTTCGTCAGCTTCATCGACACGCAAGTTCAGGCTGGCCGCTATGG
TTCAGCCACTGACGTCGTTCGGGCTGGCCTTCGCCTACTTGAAGAACACGAAGCCAAAGTGAAGGCATTACAGGACGCCT
TGATAGAAGGCGAAGAATCCGGCCCTGCCACACCCTTCGATTTCGATGCGTTCAACGCTCGCAAACGGGCGACGTTCGAG
GCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1PXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6KTA2

References