Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 132866..133467 Replicon chromosome
Accession NZ_CP020947
Organism Rhizobium sp. CIAT894

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag RHEC894_RS00640 Protein ID WP_010068843.1
Coordinates 132866..133075 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag RHEC894_RS00645 Protein ID WP_085735518.1
Coordinates 133072..133467 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RHEC894_RS00610 128150..128623 - 474 WP_085735512.1 hypothetical protein -
RHEC894_RS00615 128799..129434 + 636 WP_010068690.1 trimeric intracellular cation channel family protein -
RHEC894_RS00620 129450..129869 - 420 WP_085738804.1 transcriptional repressor -
RHEC894_RS00625 130171..130686 + 516 WP_085735514.1 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA -
RHEC894_RS00630 130731..131963 + 1233 WP_085735516.1 beta-ketoacyl-ACP synthase I -
RHEC894_RS00635 131968..132774 + 807 WP_010068842.1 enoyl-ACP reductase FabI -
RHEC894_RS00640 132866..133075 + 210 WP_010068843.1 type II toxin-antitoxin system HicA family toxin Toxin
RHEC894_RS00645 133072..133467 + 396 WP_085735518.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
RHEC894_RS00650 133471..134487 - 1017 WP_085735520.1 class I SAM-dependent methyltransferase -
RHEC894_RS00655 134620..136758 - 2139 WP_085735522.1 polyribonucleotide nucleotidyltransferase -
RHEC894_RS00660 137111..137380 - 270 WP_029531690.1 30S ribosomal protein S15 -
RHEC894_RS00665 137532..138383 - 852 WP_085735524.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7692.97 Da        Isoelectric Point: 12.1125

>T75757 WP_010068843.1 NZ_CP020947:132866-133075 [Rhizobium sp. CIAT894]
MRRSAERNSQRIIARLKREGFEVVSIKGSHHKLRRGGQSIIVPHPKKDLPIGTALAIAKQAGWNVSDKP

Download         Length: 210 bp

>T75757 NZ_CP020947:132866-133075 [Rhizobium sp. CIAT894]
TTGAGGCGCTCAGCGGAGCGAAACAGTCAGAGGATTATCGCCAGGCTGAAGCGAGAAGGCTTCGAAGTGGTTTCCATCAA
AGGCTCGCACCATAAGCTTCGGCGGGGCGGTCAGAGCATCATTGTTCCGCATCCGAAGAAAGATCTGCCGATCGGCACCG
CGCTTGCGATCGCAAAACAAGCCGGATGGAATGTGAGTGACAAACCATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14445.23 Da        Isoelectric Point: 4.3175

>AT75757 WP_085735518.1 NZ_CP020947:133072-133467 [Rhizobium sp. CIAT894]
MKYFIALVHKDMDSAFGISFPDLPAVFSAADEEEDLTANAIEALRLWAEDETLPTPSSYDEISSRQDIREQLAGGAFLTR
IPFIEDTTRTVRANVTFDKGMLDAIDKAAKERGLTRSAFLASAARKEIEAA

Download         Length: 396 bp

>AT75757 NZ_CP020947:133072-133467 [Rhizobium sp. CIAT894]
ATGAAGTATTTCATCGCTCTCGTGCACAAGGACATGGACAGCGCTTTCGGCATCAGCTTTCCGGATCTACCGGCGGTATT
CTCCGCTGCCGATGAGGAAGAAGACCTGACTGCGAACGCCATCGAAGCGCTGCGCCTCTGGGCGGAAGATGAAACCCTGC
CGACGCCTTCCTCATATGATGAGATCAGTTCTCGGCAGGATATCCGCGAGCAACTGGCCGGCGGTGCCTTTCTCACGCGT
ATTCCCTTTATCGAGGATACGACACGCACCGTTCGAGCCAATGTCACTTTCGACAAAGGCATGCTCGATGCGATCGACAA
GGCCGCTAAAGAGCGTGGCCTGACCCGTTCGGCTTTCCTTGCGAGTGCTGCCCGCAAGGAAATCGAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References