Detailed information of TA system TA075745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 2019472..2020207
• Replicon: chromosome
• Accession: NZ_CP020943
• Organism: Pantoea ananatis strain PNA 97-1R

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B9Q16_RS09710
• Protein ID: WP_089517249.1
• Coordinates: 2019472..2019864 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B9Q16_RS09715
• Protein ID: WP_104933433.1
• Coordinates: 2019854..2020207 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9Q16_RS09695	2014770..2015942	-	1173	WP_013026120.1	FMNH2-dependent alkanesulfonate monooxygenase	-
B9Q16_RS09700	2016219..2018105	+	1887	WP_072138116.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
B9Q16_RS09705	2018200..2019147	+	948	WP_015700094.1	sulfonate ABC transporter substrate-binding protein	-
B9Q16_RS09710	2019472..2019864	+	393	WP_089517249.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9Q16_RS09715	2019854..2020207	+	354	WP_104933433.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B9Q16_RS09730	2020759..2021298	-	540	WP_022623267.1	peptide-methionine (S)-S-oxide reductase MsrA	-
B9Q16_RS09735	2021661..2022728	-	1068	WP_013026114.1	two-component system sensor histidine kinase PmrB	-
B9Q16_RS09740	2022725..2023411	-	687	WP_013026113.1	two-component system response regulator PmrA	-
B9Q16_RS09745	2024298..2025086	+	789	WP_013026112.1	trehalose-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (6-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (56-99)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14959.25 Da
• Isoelectric Point: 10.1482

>T75745 WP_089517249.1 NZ_CP020943:2019472-2019864 [Pantoea ananatis]
MGFTLYVHKRFDRVFKKTRLTDSVLCYAAGDVFTGVFEADLGGGVIKKRLALHQGKRGGARTVIFFRQGTNLVYYDGWVK
NLSRKYAKEIDEDQLDTYRDVARMFFRANSEVMSLLVRSGMVREVKCNEN

Nucleotide

• Length: 393 bp

>T75745 NZ_CP020943:2019472-2019864 [Pantoea ananatis]
ATGGGTTTTACGCTTTATGTTCATAAACGTTTTGACAGAGTGTTTAAAAAAACGCGTCTGACAGACAGCGTCCTGTGTTA
CGCAGCAGGTGACGTTTTTACTGGCGTGTTTGAGGCTGACTTAGGCGGTGGCGTTATTAAAAAGCGTCTTGCTCTTCACC
AAGGCAAGCGTGGCGGCGCGCGAACGGTCATCTTCTTCAGACAAGGCACCAACCTGGTTTATTACGATGGATGGGTTAAA
AACTTGTCGAGGAAATACGCTAAAGAAATCGATGAAGATCAGCTGGATACCTACAGGGATGTGGCAAGAATGTTTTTCCG
TGCAAATAGTGAAGTGATGAGCCTGCTCGTCAGAAGCGGAATGGTCAGAGAGGTTAAATGTAATGAAAACTGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13111.16 Da
• Isoelectric Point: 6.4825

>AT75745 WP_104933433.1 NZ_CP020943:2019854-2020207 [Pantoea ananatis]
MKTEPAELSELLEDAKAFHALGLATDEELESIAKRAKNRELRARIASVKPMTATEIKDVRMRWGMSQSLVALSFGMTVDS
VSKWERGEITPSPPVMRMLQLLRDNGPELFTSKHEGI

Nucleotide

• Length: 354 bp

>AT75745 NZ_CP020943:2019854-2020207 [Pantoea ananatis]
ATGAAAACTGAACCCGCCGAATTGAGTGAACTACTTGAAGATGCGAAAGCGTTTCACGCGTTAGGACTGGCAACAGATGA
AGAATTGGAGTCCATAGCAAAGCGCGCAAAAAATCGTGAACTCCGTGCCCGTATTGCATCAGTAAAGCCCATGACAGCAA
CTGAAATCAAAGACGTGCGCATGCGTTGGGGAATGTCGCAATCGCTTGTGGCGCTCTCATTTGGCATGACGGTCGATAGC
GTATCGAAATGGGAGCGAGGTGAAATCACACCGAGCCCACCGGTGATGCGGATGCTGCAACTCCTTCGCGATAACGGCCC
TGAACTCTTTACCTCTAAGCATGAAGGTATCTAG