Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1415700..1416354 Replicon chromosome
Accession NZ_CP020933
Organism Escherichia coli strain HB-Coli0

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag B9W17_RS06950 Protein ID WP_063112724.1
Coordinates 1415947..1416354 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag B9W17_RS06945 Protein ID WP_000354046.1
Coordinates 1415700..1415966 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9W17_RS06920 1410988..1411731 + 744 WP_000951964.1 SDR family oxidoreductase -
B9W17_RS06925 1411788..1413221 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
B9W17_RS06930 1413266..1413577 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
B9W17_RS06935 1413741..1414400 + 660 WP_000250274.1 hemolysin III family protein -
B9W17_RS06940 1414477..1415457 - 981 WP_001472148.1 tRNA-modifying protein YgfZ -
B9W17_RS06945 1415700..1415966 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
B9W17_RS06950 1415947..1416354 + 408 WP_063112724.1 protein YgfX Toxin
B9W17_RS06955 1416394..1416915 - 522 WP_001055874.1 flavodoxin FldB -
B9W17_RS06960 1417027..1417923 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
B9W17_RS06965 1417948..1418658 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B9W17_RS06970 1418664..1420397 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16082.04 Da        Isoelectric Point: 11.2511

>T75711 WP_063112724.1 NZ_CP020933:1415947-1416354 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLFHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T75711 NZ_CP020933:1415947-1416354 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGTTTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT75711 WP_000354046.1 NZ_CP020933:1415700-1415966 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT75711 NZ_CP020933:1415700-1415966 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References