Detailed information of TA system TA075702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 4005012..4005534
• Replicon: chromosome
• Accession: NZ_CP020931
• Organism: Marinobacter salarius strain SMR5

Toxin (Protein)

• Gene name: -
• Uniprot ID: W5YPM9
• Locus tag: MARSALSMR5_RS18365
• Protein ID: WP_041333059.1
• Coordinates: 4005271..4005534 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W5YPD4
• Locus tag: MARSALSMR5_RS18360
• Protein ID: WP_041333061.1
• Coordinates: 4005012..4005281 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MARSALSMR5_RS18340	4000692..4002302	+	1611	WP_085681720.1	dihydrolipoyllysine-residue acetyltransferase	-
MARSALSMR5_RS18345	4002312..4004150	+	1839	WP_085681721.1	protein kinase	-
MARSALSMR5_RS18355	4004590..4004985	-	396	WP_085681722.1	VOC family protein	-
MARSALSMR5_RS18360	4005012..4005281	-	270	WP_041333061.1	hypothetical protein	Antitoxin
MARSALSMR5_RS18365	4005271..4005534	-	264	WP_041333059.1	BrnT family toxin	Toxin
MARSALSMR5_RS21545	4005713..4006537	-	825	WP_157665623.1	hypothetical protein	-
MARSALSMR5_RS18375	4006859..4007653	+	795	WP_198324870.1	IS110 family transposase	-
MARSALSMR5_RS18380	4007841..4008263	-	423	WP_085681724.1	hypothetical protein	-
MARSALSMR5_RS18385	4008366..4008659	-	294	WP_085681725.1	hypothetical protein	-
MARSALSMR5_RS18390	4008798..4009034	-	237	WP_085681726.1	hypothetical protein	-
MARSALSMR5_RS18395	4009125..4009439	-	315	WP_085681727.1	hypothetical protein	-
MARSALSMR5_RS18400	4009519..4010310	-	792	WP_085681728.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	4004590..4011646	7056

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10171.52 Da
• Isoelectric Point: 5.7528

>T75702 WP_041333059.1 NZ_CP020931:c4005534-4005271 [Marinobacter salarius]
MDEFEFDEAKSQANLDKHGIDFVAAQGLWKDPYLLEIGAKSEDEQRFLLIGKIGEKHWSAVVTYRDARIRLISVRRSRKK
EVELYES

Nucleotide

• Length: 264 bp

>T75702 NZ_CP020931:c4005534-4005271 [Marinobacter salarius]
ATGGATGAATTTGAATTCGACGAAGCCAAAAGCCAGGCCAATCTGGACAAACACGGTATCGATTTCGTTGCTGCCCAAGG
GCTGTGGAAAGATCCGTACCTGCTGGAGATCGGCGCAAAATCAGAGGATGAGCAGAGGTTTTTGCTGATAGGCAAGATTG
GTGAAAAGCACTGGTCGGCTGTCGTCACGTACAGGGATGCTCGTATTCGTCTGATTTCAGTCAGACGTTCCCGCAAGAAG
GAGGTTGAGCTCTATGAAAGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10071.23 Da
• Isoelectric Point: 4.8838

>AT75702 WP_041333061.1 NZ_CP020931:c4005281-4005012 [Marinobacter salarius]
MKAKDFDKKFEEGQEDIVDDLDLSSARRVNQEQKRINVDFPAWVVESLDREAARYGVTRQSIIKVWLVERLQAESANKPL
NGDAAGGAH

Nucleotide

• Length: 270 bp

>AT75702 NZ_CP020931:c4005281-4005012 [Marinobacter salarius]
ATGAAAGCTAAAGACTTCGATAAAAAGTTTGAGGAAGGTCAAGAAGATATTGTTGATGACCTGGACCTGTCGTCTGCTCG
TCGCGTTAATCAGGAACAAAAGCGAATCAACGTCGACTTCCCGGCTTGGGTTGTGGAGTCGTTGGACCGTGAGGCTGCGC
GCTACGGAGTTACCCGTCAATCGATCATCAAGGTGTGGCTGGTGGAGCGTCTTCAGGCAGAATCTGCTAACAAGCCGCTC
AATGGTGACGCCGCAGGCGGCGCACATTAG

Structures

Toxin

• AlphaFold DB: W5YPM9

Antitoxin

• AlphaFold DB: W5YPD4