Detailed information of TA system TA075693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 32889..33387
• Replicon: plasmid unnamed2
• Accession: NZ_CP020924
• Organism: Salmonella enterica subsp. enterica strain 16A242

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: A0A0K6A0X9
• Locus tag: B6N26_RS26015
• Protein ID: WP_000702249.1
• Coordinates: 32889..33155 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: A0A3H7VMJ5
• Locus tag: B6N26_RS26020
• Protein ID: WP_001450803.1
• Coordinates: 33145..33387 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6N26_RS26560	28047..28334	-	288	WP_000332248.1	helix-turn-helix transcriptional regulator	-
B6N26_RS25975	28533..28871	+	339	WP_000612441.1	helix-turn-helix domain-containing protein	-
B6N26_RS25980	29245..30249	-	1005	WP_001208090.1	replication initiation protein	-
B6N26_RS26000	31930..32253	+	324	WP_000432877.1	hypothetical protein	-
B6N26_RS26005	32294..32518	+	225	WP_000866040.1	hypothetical protein	-
B6N26_RS26010	32614..32838	+	225	WP_000749828.1	hypothetical protein	-
B6N26_RS26015	32889..33155	+	267	WP_000702249.1	hypothetical protein	Toxin
B6N26_RS26020	33145..33387	+	243	WP_001450803.1	hypothetical protein	Antitoxin
B6N26_RS26030	33830..34153	+	324	WP_000432877.1	hypothetical protein	-
B6N26_RS26035	34193..34417	+	225	WP_000866040.1	hypothetical protein	-
B6N26_RS26040	34513..34737	+	225	WP_000749828.1	hypothetical protein	-
B6N26_RS26045	34788..35054	+	267	WP_000702249.1	hypothetical protein	-
B6N26_RS26050	35044..35286	+	243	WP_001450803.1	hypothetical protein	-
B6N26_RS26060	35729..36058	+	330	WP_000449468.1	hypothetical protein	-
B6N26_RS26065	36116..36394	+	279	WP_000545936.1	hypothetical protein	-
B6N26_RS26070	36831..37013	+	183	WP_000833471.1	type II toxin-antitoxin system HicA family toxin	-
B6N26_RS26075	37038..37475	+	438	WP_000466317.1	type II toxin-antitoxin system HicB family antitoxin	-
B6N26_RS26080	37504..38208	-	705	WP_001279865.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..65419	65419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-78)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 11425.51 Da
• Isoelectric Point: 12.7445

>T75693 WP_000702249.1 NZ_CP020924:32889-33155 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKK

Nucleotide

• Length: 267 bp

>T75693 NZ_CP020924:32889-33155 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 10400.12 Da
• Isoelectric Point: 12.7030

>AT75693 WP_001450803.1 NZ_CP020924:33145-33387 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Nucleotide

• Length: 243 bp

>AT75693 NZ_CP020924:33145-33387 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Structures

Toxin

• AlphaFold DB: A0A0K6A0X9

Antitoxin

• AlphaFold DB: A0A3H7VMJ5