Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 93231..93756 Replicon plasmid unnamed1
Accession NZ_CP020923
Organism Salmonella enterica subsp. enterica strain 16A242

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag B6N26_RS25630 Protein ID WP_001159863.1
Coordinates 93231..93536 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag B6N26_RS25635 Protein ID WP_000813641.1
Coordinates 93538..93756 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6N26_RS25590 88611..89171 - 561 WP_071953347.1 inverse autotransporter beta domain-containing protein -
B6N26_RS26535 89327..89614 + 288 WP_071530243.1 hypothetical protein -
B6N26_RS25595 89891..90376 - 486 WP_000905606.1 membrane protein -
B6N26_RS25600 90370..90879 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
B6N26_RS25610 90883..91596 - 714 Protein_108 EAL domain-containing protein -
B6N26_RS25615 91605..92387 - 783 WP_000082169.1 site-specific integrase -
B6N26_RS25620 92422..92942 - 521 Protein_110 cytoplasmic protein -
B6N26_RS25625 92939..93229 - 291 WP_001266176.1 hypothetical protein -
B6N26_RS25630 93231..93536 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
B6N26_RS25635 93538..93756 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
B6N26_RS25640 94432..94953 + 522 WP_010999942.1 hypothetical protein -
B6N26_RS25650 95437..95733 + 297 WP_001687482.1 hypothetical protein -
B6N26_RS25655 96227..97216 + 990 Protein_116 RepB family plasmid replication initiator protein -
B6N26_RS26450 97475..97811 - 337 Protein_117 site-specific integrase -
B6N26_RS25670 98088..98469 - 382 Protein_118 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..116677 116677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-138)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T75692 WP_001159863.1 NZ_CP020923:c93536-93231 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T75692 NZ_CP020923:c93536-93231 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT75692 WP_000813641.1 NZ_CP020923:c93756-93538 [Salmonella enterica subsp. enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT75692 NZ_CP020923:c93756-93538 [Salmonella enterica subsp. enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References