Detailed information of TA system TA075688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 5686567..5687228
• Replicon: chromosome
• Accession: NZ_CP020917
• Organism: Achromobacter denitrificans strain PR1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3R9GKR9
• Locus tag: B9P52_RS26405
• Protein ID: WP_062682299.1
• Coordinates: 5686567..5686980 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: B9P52_RS26410
• Protein ID: WP_062682298.1
• Coordinates: 5686977..5687228 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9P52_RS26385	5681612..5682211	-	600	WP_062682301.1	C40 family peptidase	-
B9P52_RS26390	5682545..5684041	+	1497	WP_062682325.1	AMP nucleosidase	-
B9P52_RS26395	5684272..5685756	+	1485	WP_088448558.1	amino acid permease	-
B9P52_RS26400	5685666..5686343	-	678	WP_088447870.1	FecR family protein	-
B9P52_RS32380	5686352..5686558	-	207	WP_157672764.1	hypothetical protein	-
B9P52_RS26405	5686567..5686980	-	414	WP_062682299.1	type II toxin-antitoxin system VapC family toxin	Toxin
B9P52_RS26410	5686977..5687228	-	252	WP_062682298.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B9P52_RS26415	5687380..5688351	+	972	WP_088447871.1	hypothetical protein	-
B9P52_RS26420	5688409..5689338	-	930	WP_088148891.1	YicC family protein	-
B9P52_RS26425	5689540..5690259	+	720	WP_172600300.1	ribonuclease PH	-
B9P52_RS26430	5690568..5691965	+	1398	WP_082775797.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15466.80 Da
• Isoelectric Point: 5.2418

>T75688 WP_062682299.1 NZ_CP020917:c5686980-5686567 [Achromobacter denitrificans]
MSYLVDTNVLSELRRKQPDGNVVRWLEQRPATTLFLSALTMGELRKGIELMPEGERKRSYLDWLEVELPRFFSGRVLAID
EPVADCWGRLVAQAGRALPAIDSLLAATALAHGLTLVTRNERDFQHPGLDVINPWEV

Nucleotide

• Length: 414 bp

>T75688 NZ_CP020917:c5686980-5686567 [Achromobacter denitrificans]
TTGAGCTATCTCGTGGATACCAATGTCCTGTCGGAGTTGCGTCGAAAGCAACCGGACGGCAACGTGGTCAGGTGGTTGGA
GCAGCGCCCCGCCACAACACTATTCCTATCCGCATTGACGATGGGCGAGCTTCGCAAAGGCATCGAACTGATGCCGGAGG
GCGAACGAAAACGCAGTTATCTGGACTGGCTGGAAGTTGAGCTTCCCCGGTTCTTCAGCGGCCGCGTGCTGGCCATCGAC
GAACCCGTCGCGGATTGCTGGGGACGTTTGGTGGCTCAAGCAGGGCGCGCGTTGCCGGCCATCGACAGTTTGCTGGCGGC
CACGGCGCTCGCGCACGGACTGACACTGGTCACGCGCAACGAACGGGATTTCCAACATCCGGGCCTGGATGTCATCAACC
CCTGGGAAGTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9054.16 Da
• Isoelectric Point: 5.0760

>AT75688 WP_062682298.1 NZ_CP020917:c5687228-5686977 [Achromobacter denitrificans]
MHVWQMQEAKSRLSEVVKAAGTQGPQEITVHGRSVAVVLSRADFDKLSGTGESLVAFMRRSPLAGDEDLAFPRDDSPTRE
EGL

Nucleotide

• Length: 252 bp

>AT75688 NZ_CP020917:c5687228-5686977 [Achromobacter denitrificans]
ATGCACGTCTGGCAAATGCAGGAAGCCAAATCCCGCTTGTCCGAAGTCGTCAAAGCGGCCGGAACCCAAGGTCCACAGGA
AATCACCGTGCACGGCCGTTCTGTGGCTGTCGTGCTCTCTCGGGCGGACTTCGACAAACTTTCAGGCACGGGGGAATCTC
TGGTCGCCTTCATGCGCCGCTCTCCACTGGCCGGAGATGAAGACCTCGCCTTTCCCCGTGACGACAGCCCGACGCGCGAG
GAAGGACTTTGA

Structures

Toxin

• AlphaFold DB: A0A3R9GKR9