Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 958064..958638 Replicon plasmid pRetNXC12e
Accession NZ_CP020911
Organism Rhizobium etli strain NXC12

Toxin (Protein)


Gene name vapC Uniprot ID S5SHE0
Locus tag NXC12_RS32815 Protein ID WP_020919987.1
Coordinates 958064..958429 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID S5SXW7
Locus tag NXC12_RS32820 Protein ID WP_011428858.1
Coordinates 958423..958638 (-) Length 72 a.a.

Genomic Context

NXC12_RS32800NXC12_RS32805NXC12_RS32810NXC12_RS32845NXC12_RS33395NXC12_RS32815NXC12_RS32820NXC12_RS32830NXC12_RS32835NXC12_RS32840
Location: 953348..954733 (1386 bp)
Type: Others
Protein ID: WP_086084484.1
Location: 954754..956577 (1824 bp)
Type: Others
Protein ID: WP_086084549.1
Location: 956913..957215 (303 bp)
Type: Others
Protein ID: WP_020919986.1
Location: 961873..962307 (435 bp)
Type: Others
Protein ID: WP_020919991.1
Location: 957212..957514 (303 bp)
Type: Others
Protein ID: WP_155249502.1
Location: 958064..958429 (366 bp)
Type: Toxin
Protein ID: WP_020919987.1
Location: 958423..958638 (216 bp)
Type: Antitoxin
Protein ID: WP_011428858.1
Location: 958962..959645 (684 bp)
Type: Others
Protein ID: WP_020919988.1
Location: 960022..961068 (1047 bp)
Type: Others
Protein ID: WP_086084485.1
Location: 961065..961787 (723 bp)
Type: Others
Protein ID: WP_086084486.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NXC12_RS32800953348..954733+1386WP_086084484.1DegQ family serine endoprotease-
NXC12_RS32805954754..956577+1824WP_086084549.1ATP-dependent zinc metalloprotease FtsH-
NXC12_RS32810956913..957215+303WP_020919986.1DUF982 domain-containing protein-
NXC12_RS33395957212..957514-303WP_155249502.1GNAT family N-acetyltransferase-
NXC12_RS32815958064..958429-366WP_020919987.1type II toxin-antitoxin system VapC family toxinToxin
NXC12_RS32820958423..958638-216WP_011428858.1ribbon-helix-helix domain-containing proteinAntitoxin
NXC12_RS32830958962..959645-684WP_020919988.1redoxin domain-containing protein-
NXC12_RS32835960022..961068-1047WP_086084485.1S-adenosylmethionine:tRNA ribosyltransferase-isomerase-
NXC12_RS32840961065..961787-723WP_086084486.1SDR family oxidoreductase-
NXC12_RS32845961873..962307+435WP_020919991.1redox-sensitive transcriptional activator SoxR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid-htpB1..978479978479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13686.05 Da        Isoelectric Point: 7.2029

>T75681 WP_020919987.1 NZ_CP020911:c958429-958064 [Rhizobium etli]
MVKSLFDTNVLIDYLNAVPQARDELRRYPEKAISIITWMEVLVGAKPEVAIGTRAFLAGFAVIAVDDAIAERAVSLRQLH
RIKLPDAIIWATANVHSMLLITRNTKDFPREMPDIRVPYEI

Download         Length: 366 bp

>T75681 NZ_CP020911:c958429-958064 [Rhizobium etli]
ATGGTAAAGTCTCTGTTCGACACTAATGTCTTGATCGATTATCTCAACGCAGTTCCACAAGCGCGAGACGAACTGAGGAG
ATATCCCGAAAAGGCGATCAGCATTATCACCTGGATGGAGGTTCTCGTCGGTGCCAAGCCTGAGGTGGCAATCGGAACGC
GCGCTTTCCTGGCCGGCTTTGCGGTCATCGCTGTCGATGACGCCATAGCCGAACGAGCAGTTTCTCTGCGACAACTTCAT
CGTATCAAGCTTCCAGATGCCATCATCTGGGCAACGGCCAATGTTCACTCGATGTTGCTGATCACCCGAAACACGAAGGA
TTTCCCTCGTGAAATGCCGGACATACGAGTGCCATACGAAATTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8233.40 Da        Isoelectric Point: 6.3273

>AT75681 WP_011428858.1 NZ_CP020911:c958638-958423 [Rhizobium etli]
MRTLVDIGDPEVKALDRLAQREKMSRAALIRKAINDFLARNNADIEAEAFGLWGDRKIDGLAYQENMRREW

Download         Length: 216 bp

>AT75681 NZ_CP020911:c958638-958423 [Rhizobium etli]
ATGAGAACGTTGGTAGATATCGGCGACCCAGAAGTCAAAGCGCTGGATCGGCTGGCACAGCGGGAAAAAATGTCGAGAGC
AGCGCTGATCCGAAAGGCGATCAATGACTTCCTGGCTAGGAACAATGCCGATATCGAAGCAGAAGCGTTCGGGCTCTGGG
GCGATCGAAAGATCGATGGTTTGGCCTATCAGGAAAACATGCGCCGCGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS5SHE0

Antitoxin

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Source
ID
Structure
AlphaFold DBS5SXW7

References