Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 222935..223686 Replicon plasmid pK66-45-1
Accession NZ_CP020902
Organism Klebsiella pneumoniae strain K66-45

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag B5G58_RS28210 Protein ID WP_014386536.1
Coordinates 223204..223686 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag B5G58_RS28205 Protein ID WP_004902250.1
Coordinates 222935..223213 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5G58_RS31390 218563..218988 - 426 WP_000522996.1 organomercurial transporter MerC -
B5G58_RS31395 219016..219291 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
B5G58_RS28170 219307..219687 - 381 WP_001294654.1 mercuric ion transporter MerT -
B5G58_RS28175 219759..220214 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
B5G58_RS28180 220867..221325 + 459 WP_014386535.1 hypothetical protein -
B5G58_RS28195 222155..222496 + 342 WP_004902257.1 hypothetical protein -
B5G58_RS28200 222604..222816 + 213 WP_004902255.1 hypothetical protein -
B5G58_RS28205 222935..223213 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
B5G58_RS28210 223204..223686 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
B5G58_RS28225 224721..225260 + 540 WP_004902239.1 hypothetical protein -
B5G58_RS28230 225365..225757 + 393 WP_032442757.1 hypothetical protein -
B5G58_RS28235 225858..226613 + 756 WP_004902235.1 DUF2971 domain-containing protein -
B5G58_RS28240 226640..227287 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / qnrS1 / aph(3')-VI / blaNDM-1 / blaCTX-M-15 - 1..338512 338512


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T75671 WP_014386536.1 NZ_CP020902:223204-223686 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T75671 NZ_CP020902:223204-223686 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT75671 WP_004902250.1 NZ_CP020902:222935-223213 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT75671 NZ_CP020902:222935-223213 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References