75662

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3939653..3940169 Replicon chromosome
Accession NZ_CP020901
Organism Klebsiella pneumoniae strain K66-45

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag B5G58_RS19585 Protein ID WP_002886902.1
Coordinates 3939653..3939937 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag B5G58_RS19590 Protein ID WP_002886901.1
Coordinates 3939927..3940169 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5G58_RS19565 3935137..3935445 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
B5G58_RS31920 3935530..3935703 + 174 WP_002886906.1 hypothetical protein -
B5G58_RS19570 3935706..3936449 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
B5G58_RS19575 3936806..3938944 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
B5G58_RS19580 3939185..3939649 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
B5G58_RS19585 3939653..3939937 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5G58_RS19590 3939927..3940169 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B5G58_RS19595 3940247..3942157 - 1911 WP_004152270.1 BglG family transcription antiterminator -
B5G58_RS19600 3942180..3943334 - 1155 WP_002886900.1 lactonase family protein -
B5G58_RS19605 3943400..3944140 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T75662 WP_002886902.1 NZ_CP020901:c3939937-3939653 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T75662 NZ_CP020901:c3939937-3939653 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT75662 WP_002886901.1 NZ_CP020901:c3940169-3939927 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT75662 NZ_CP020901:c3940169-3939927 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References