Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4456954..4457621 Replicon chromosome
Accession NZ_CP020885
Organism Xanthomonas citri pv. citri strain TX160149

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag B7L66_RS20165 Protein ID WP_005916679.1
Coordinates 4457205..4457621 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag B7L66_RS20160 Protein ID WP_005916676.1
Coordinates 4456954..4457208 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7L66_RS20135 4453076..4453295 + 220 Protein_3750 RNA 2'-phosphotransferase -
B7L66_RS20140 4453452..4454717 + 1266 WP_015463799.1 cardiolipin synthase B -
B7L66_RS20145 4454743..4455270 - 528 WP_005916668.1 hypothetical protein -
B7L66_RS20150 4455509..4455715 + 207 WP_003489327.1 hypothetical protein -
B7L66_RS20155 4455702..4456808 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
B7L66_RS20160 4456954..4457208 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
B7L66_RS20165 4457205..4457621 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
B7L66_RS26015 4457743..4457955 - 213 WP_015472900.1 hypothetical protein -
B7L66_RS26020 4458074..4458286 - 213 WP_015472901.1 hypothetical protein -
B7L66_RS20170 4458543..4460162 + 1620 WP_015463800.1 hypothetical protein -
B7L66_RS20175 4460266..4460664 - 399 WP_004429277.1 DUF2384 domain-containing protein -
B7L66_RS20180 4460980..4461411 + 432 WP_005922907.1 hypothetical protein -
B7L66_RS20185 4461440..4461766 - 327 Protein_3762 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T75628 WP_005916679.1 NZ_CP020885:4457205-4457621 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T75628 NZ_CP020885:4457205-4457621 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT75628 WP_005916676.1 NZ_CP020885:4456954-4457208 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT75628 NZ_CP020885:4456954-4457208 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References