Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 275754..276390 Replicon chromosome
Accession NZ_CP020880
Organism Bacillus horikoshii strain 20a

Toxin (Protein)


Gene name mazF Uniprot ID A0A0K6GQX7
Locus tag B4U37_RS01440 Protein ID WP_010195163.1
Coordinates 276040..276390 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0N0EA03
Locus tag B4U37_RS01435 Protein ID WP_010195162.1
Coordinates 275754..276035 (+) Length 94 a.a.

Genomic Context

B4U37_RS01420B4U37_RS01425B4U37_RS01430B4U37_RS01435B4U37_RS01440B4U37_RS01445B4U37_RS01450B4U37_RS01455B4U37_RS01460B4U37_RS01465B4U37_RS01470B4U37_RS01475B4U37_RS01415
Location: 272698..273063 (366 bp)
Type: Others
Protein ID: WP_088020081.1
Location: 273226..274248 (1023 bp)
Type: Others
Protein ID: WP_010195160.1
Location: 274439..275608 (1170 bp)
Type: Others
Protein ID: WP_088016777.1
Location: 275754..276035 (282 bp)
Type: Antitoxin
Protein ID: WP_010195162.1
Location: 276040..276390 (351 bp)
Type: Toxin
Protein ID: WP_010195163.1
Location: 276688..277518 (831 bp)
Type: Others
Protein ID: WP_010195164.1
Location: 277515..277871 (357 bp)
Type: Others
Protein ID: WP_010195165.1
Location: 277875..278276 (402 bp)
Type: Others
Protein ID: WP_010195167.1
Location: 278292..279299 (1008 bp)
Type: Others
Protein ID: WP_010195168.1
Location: 279376..279684 (309 bp)
Type: Others
Protein ID: WP_010195171.1
Location: 279733..280209 (477 bp)
Type: Others
Protein ID: WP_010195173.1
Location: 280184..280969 (786 bp)
Type: Others
Protein ID: WP_010195175.1
Location: 271866..272579 (714 bp)
Type: Others
Protein ID: WP_010195154.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B4U37_RS01415271866..272579-714WP_010195154.1rhomboid family intramembrane serine protease-
B4U37_RS01420272698..273063+366WP_088020081.1holo-ACP synthase-
B4U37_RS01425273226..274248+1023WP_010195160.1outer membrane lipoprotein carrier protein LolA-
B4U37_RS01430274439..275608+1170WP_088016777.1alanine racemase-
B4U37_RS01435275754..276035+282WP_010195162.1hypothetical proteinAntitoxin
B4U37_RS01440276040..276390+351WP_010195163.1type II toxin-antitoxin system endoribonuclease NdoAToxin
B4U37_RS01445276688..277518+831WP_010195164.1STAS domain-containing protein-
B4U37_RS01450277515..277871+357WP_010195165.1STAS domain-containing protein-
B4U37_RS01455277875..278276+402WP_010195167.1anti-sigma regulatory factor-
B4U37_RS01460278292..279299+1008WP_010195168.1PP2C family protein-serine/threonine phosphatase-
B4U37_RS01465279376..279684+309WP_010195171.1STAS domain-containing protein-
B4U37_RS01470279733..280209+477WP_010195173.1anti-sigma B factor RsbW-
B4U37_RS01475280184..280969+786WP_010195175.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8891

>T75618 WP_010195163.1 NZ_CP020880:276040-276390 [Bacillus horikoshii]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T75618 NZ_CP020880:276040-276390 [Bacillus horikoshii]
TTGATTGTCAAACGCGGTGACGTTTATTTTGCTGATTTATCCCCGGTTGTTGGGTCTGAGCAAGGAGGCGTTCGACCAGT
ACTTGTCATCCAAAATGATATCGGAAATCGATTTAGCCCGACCGTTATAGTAGCTGCCATTACTGCTCAAATCCAAAAAG
CCAAACTCCCAACACATGTAGAGATCGATGCGAAGCGTTATGGTTTTGAACGTGACTCTGTTATCCTGCTCGAACAAATT
CGAACAATTGATAAACAAAGATTAACGGACAAAATTACTCATCTTGACGAAGAGATGATGGACAAAGTGGATGAGGCGCT
TCAAATAAGCTTAGGACTTATTGACTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10717.21 Da        Isoelectric Point: 7.0161

>AT75618 WP_010195162.1 NZ_CP020880:275754-276035 [Bacillus horikoshii]
VSESSATTEILIRLPQNLVSELDGLVKQENGNRNELIFQATKMYLRERKKRQIRESMRRGYMEMSKINLNIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT75618 NZ_CP020880:275754-276035 [Bacillus horikoshii]
GTGTCTGAATCCAGCGCAACAACTGAAATCTTGATTCGATTACCTCAAAACTTAGTGTCGGAATTAGATGGTTTGGTAAA
ACAAGAAAACGGCAATCGAAACGAATTAATCTTTCAAGCAACAAAGATGTATCTTCGCGAGCGCAAAAAGCGTCAAATTC
GCGAGTCCATGAGACGTGGCTACATGGAAATGTCTAAAATCAATCTAAACATTGCATCTGAAGCTTTCTTGGCTGAATAT
GAGGCGGAGCATACGGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K6GQX7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0N0EA03

References