Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1819860..1820521 Replicon chromosome
Accession NZ_CP020873
Organism Prosthecochloris sp. HL-130-GSB

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B9H02_RS08635 Protein ID WP_085660023.1
Coordinates 1819860..1820258 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B9H02_RS08640 Protein ID WP_085660024.1
Coordinates 1820255..1820521 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9H02_RS08595 1814925..1815319 - 395 Protein_1679 DUF2384 domain-containing protein -
B9H02_RS08600 1815443..1816487 + 1045 Protein_1680 Fic family protein -
B9H02_RS08605 1816680..1817252 + 573 WP_085660019.1 zeta toxin family protein -
B9H02_RS08610 1817249..1817440 + 192 WP_085660012.1 hypothetical protein -
B9H02_RS08615 1817668..1817991 - 324 WP_085660020.1 hypothetical protein -
B9H02_RS11845 1817988..1818506 - 519 WP_198166333.1 hypothetical protein -
B9H02_RS08625 1818516..1818866 - 351 WP_085660021.1 addiction module protein -
B9H02_RS08635 1819860..1820258 - 399 WP_085660023.1 type II toxin-antitoxin system VapC family toxin Toxin
B9H02_RS08640 1820255..1820521 - 267 WP_085660024.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
B9H02_RS08645 1820981..1822901 - 1921 Protein_1688 glutamine--fructose-6-phosphate transaminase (isomerizing) -
B9H02_RS08650 1822911..1824037 - 1127 Protein_1689 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
B9H02_RS08655 1824154..1825358 - 1205 Protein_1690 UDP-N-acetyl-D-mannosamine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1803116..1825358 22242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-42)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14705.14 Da        Isoelectric Point: 7.3563

>T75615 WP_085660023.1 NZ_CP020873:c1820258-1819860 [Prosthecochloris sp. HL-130-GSB]
MMLYMLDTNIASHVIKGDIAEVRERLIAVPMHSVTISAVTQAELFYGLAKRSYPKGLSLRVHEFMLRVRVLDWDRDAAVS
YSQLRVICERSGVALSPLDYMIAAHALSSGAVLVTRDKAFGRVPDGLAVEEW

Download         Length: 399 bp

>T75615 NZ_CP020873:c1820258-1819860 [Prosthecochloris sp. HL-130-GSB]
ATGATGCTGTATATGCTTGATACCAATATTGCCAGTCATGTCATCAAGGGGGATATTGCTGAAGTGCGTGAGCGGCTGAT
TGCCGTACCTATGCACAGCGTAACGATATCTGCGGTTACTCAGGCGGAATTGTTCTATGGCCTTGCGAAGCGATCCTATC
CGAAAGGACTTTCCTTGCGTGTTCACGAATTCATGTTACGGGTAAGGGTGCTCGACTGGGATCGGGATGCCGCAGTTTCC
TACAGCCAGCTTCGTGTCATATGTGAACGGTCGGGAGTTGCTCTTTCTCCCCTGGATTATATGATAGCTGCACATGCCTT
ATCCTCTGGCGCTGTACTTGTTACAAGGGATAAAGCGTTTGGCCGGGTTCCGGATGGACTTGCCGTGGAGGAATGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10247.38 Da        Isoelectric Point: 4.2066

>AT75615 WP_085660024.1 NZ_CP020873:c1820521-1820255 [Prosthecochloris sp. HL-130-GSB]
MTVTAKIFISGRSQAVRLPREFRFEGKEVFIRRDPLTGDVILSRCPDSWSGLFDLDATTEVPEDFLGEEDRRQQEQVRDP
FDGWEEPE

Download         Length: 267 bp

>AT75615 NZ_CP020873:c1820521-1820255 [Prosthecochloris sp. HL-130-GSB]
ATGACTGTTACAGCGAAGATTTTTATATCCGGGCGAAGCCAGGCTGTTCGTTTGCCCCGGGAGTTTCGTTTCGAAGGTAA
AGAGGTTTTTATTCGTCGTGATCCCTTGACTGGTGACGTGATCTTGTCGCGCTGCCCCGATTCCTGGTCAGGTTTGTTTG
ATCTCGATGCGACAACCGAGGTTCCTGAAGATTTCCTTGGTGAGGAAGACCGCAGGCAGCAGGAACAGGTGCGCGATCCT
TTCGACGGCTGGGAGGAACCTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References