Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1874747..1875300 Replicon chromosome
Accession NZ_CP020872
Organism Dickeya fangzhongdai strain PA1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag B6N31_RS08325 Protein ID WP_121480011.1
Coordinates 1874986..1875300 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag B6N31_RS08320 Protein ID WP_121480010.1
Coordinates 1874747..1874983 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6N31_RS08305 1871074..1872087 - 1014 WP_121480007.1 SIR2 family protein -
B6N31_RS08310 1872301..1872930 - 630 WP_162942922.1 hypothetical protein -
B6N31_RS08315 1873472..1874419 + 948 WP_121480009.1 DUF1738 domain-containing protein -
B6N31_RS08320 1874747..1874983 + 237 WP_121480010.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
B6N31_RS08325 1874986..1875300 + 315 WP_121480011.1 CcdB family protein Toxin
B6N31_RS08335 1875804..1876400 + 597 WP_036112524.1 hypothetical protein -
B6N31_RS08340 1876550..1877296 - 747 WP_121480012.1 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
B6N31_RS08345 1877305..1879167 - 1863 WP_121480013.1 type IV secretion system DNA-binding domain-containing protein -
B6N31_RS08355 1879863..1880165 - 303 WP_038908373.1 conjugal transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp / vgrG1 1868996..1914539 45543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11457.41 Da        Isoelectric Point: 7.9859

>T75604 WP_121480011.1 NZ_CP020872:1874986-1875300 [Dickeya fangzhongdai]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRAQVKAAIDFLIDGI

Download         Length: 315 bp

>T75604 NZ_CP020872:1874986-1875300 [Dickeya fangzhongdai]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGCCGCCGACCGGAGCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGTAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGCATCCCTGTCCAGGCTCTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTGCTCAGGTAAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9048.03 Da        Isoelectric Point: 5.6998

>AT75604 WP_121480010.1 NZ_CP020872:1874747-1874983 [Dickeya fangzhongdai]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEANKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT75604 NZ_CP020872:1874747-1874983 [Dickeya fangzhongdai]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
TATTAACCTGAGTGCTACTCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTTATGAAGCGAACAAATGGCAGGAAGAGA
ACAGGGAAGCCATTGACGCATTAAACCGTTTTCATGATGAACACGGCTGTTTCAGCGATGAATACAGGACCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References