Detailed information of TA system TA075601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1028409..1028935
• Replicon: chromosome
• Accession: NZ_CP020872
• Organism: Dickeya fangzhongdai strain PA1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: B6N31_RS04635
• Protein ID: WP_038918043.1
• Coordinates: 1028409..1028714 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: B6N31_RS04640
• Protein ID: WP_038918044.1
• Coordinates: 1028717..1028935 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6N31_RS04625	1025022..1027031	+	2010	WP_193745938.1	ATP-dependent helicase	-
B6N31_RS04630	1027033..1028298	+	1266	WP_038918041.1	GIY-YIG nuclease family protein	-
B6N31_RS04635	1028409..1028714	-	306	WP_038918043.1	type II toxin-antitoxin system toxin CcdB	Toxin
B6N31_RS04640	1028717..1028935	-	219	WP_038918044.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
B6N31_RS04645	1028994..1029737	-	744	WP_038918045.1	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
B6N31_RS04655	1030641..1030982	-	342	WP_121479762.1	hypothetical protein	-
B6N31_RS04660	1031439..1032701	-	1263	WP_038918047.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1016659..1032701	16042

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11821.72 Da
• Isoelectric Point: 4.6873

>T75601 WP_038918043.1 NZ_CP020872:c1028714-1028409 [Dickeya fangzhongdai]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKMLFPLLRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T75601 NZ_CP020872:c1028714-1028409 [Dickeya fangzhongdai]
ATGCAATTCATTGTTTATCAATACAAACGCGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
ACCCAAGCGACGCATGGTCATTCCGCTTATCGAATCGCATCACCTGTCTGAGAAAGTGAATAAGATGTTGTTCCCTCTGC
TTCGCATCGATGGCGAAGATTATCGGTTGATGACAACTGAACTATCGAGCGTTCCTGTTGAGGTTATTGGTGAAGAAATC
GCGGATCTTGGCGACTACGCTGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8220.17 Da
• Isoelectric Point: 7.0142

>AT75601 WP_038918044.1 NZ_CP020872:c1028935-1028717 [Dickeya fangzhongdai]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNEAIGKEARRIRAEEWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT75601 NZ_CP020872:c1028935-1028717 [Dickeya fangzhongdai]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCCGCCGGGGTCAATATTTCCGGGCT
GGTGAATGAGGCCATTGGCAAAGAAGCCCGCCGCATCAGGGCTGAAGAGTGGAAGAAGGAGAATCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA