Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 470186..471830 Replicon chromosome
Accession NZ_CP020872
Organism Dickeya fangzhongdai strain PA1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B6N31_RS02190 Protein ID WP_121479600.1
Coordinates 470496..471830 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B6N31_RS02185 Protein ID WP_121479599.1
Coordinates 470186..470491 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6N31_RS02165 465757..466875 + 1119 WP_038917649.1 LPS export ABC transporter permease LptF -
B6N31_RS02170 466877..467947 + 1071 WP_038917650.1 LPS export ABC transporter permease LptG -
B6N31_RS02180 468442..469698 + 1257 WP_121479598.1 tyrosine-type recombinase/integrase -
B6N31_RS02185 470186..470491 + 306 WP_121479599.1 helix-turn-helix transcriptional regulator Antitoxin
B6N31_RS02190 470496..471830 + 1335 WP_121479600.1 type II toxin-antitoxin system HipA family toxin Toxin
B6N31_RS02195 472106..474142 - 2037 WP_121479601.1 AAA family ATPase -
B6N31_RS02200 474135..474668 - 534 WP_205571545.1 ash family protein -
B6N31_RS02205 474668..474868 - 201 WP_005971237.1 AlpA family transcriptional regulator -
B6N31_RS02210 474871..475329 - 459 Protein_420 integrase domain-containing protein -
B6N31_RS02215 475410..476521 + 1112 WP_121479603.1 IS3 family transposase -
B6N31_RS02220 476538..476816 + 279 Protein_422 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 468442..476816 8374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50796.91 Da        Isoelectric Point: 6.1903

>T75599 WP_121479600.1 NZ_CP020872:470496-471830 [Dickeya fangzhongdai]
MPRTQQRLAIWMNGIQVGFWEKSRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGGIQLLNGNEEPTDLFSVKYRPLCDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMGDI
ISRTPEVIERVSSLLPESFPLELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

>T75599 NZ_CP020872:470496-471830 [Dickeya fangzhongdai]
ATGCCTCGAACACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGAGCCGAGGCGAAGA
TAGGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAAGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGATTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGAAGAGACTGTGTTGGCGGAATACA
GTTACTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGCTTTGTGACGCAGAGATTGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAAGGCAATGGTGTTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTGTGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTTGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTC
GACAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCGGGGATTTCCGATATTATGACCATACTGAGTCATTCAGAGCAGGCAGAGC
AGGACAAAGCGCAATTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCAACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCGCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGTAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGTAGACGACAGGTTGAAGCCATGATGGGTGATATT
ATATCCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACTAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11331.14 Da        Isoelectric Point: 10.5325

>AT75599 WP_121479599.1 NZ_CP020872:470186-470491 [Dickeya fangzhongdai]
MNTVYPLKTLNQLRPLLIGFRKAKGMTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp

>AT75599 NZ_CP020872:470186-470491 [Dickeya fangzhongdai]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAGGGAATGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAACAAACCTATGCCCGTTTGGAAGCAAACCCCGGAAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAGAGTACATTTCTCGATG
TCGTCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References