Detailed information of TA system TA075596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2484511..2485122
• Replicon: chromosome
• Accession: NZ_CP020870
• Organism: Xylella fastidiosa subsp. pauca strain De Donno

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B9J09_RS11820
• Protein ID: WP_046420946.1
• Coordinates: 2484823..2485122 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9P9V8
• Locus tag: B9J09_RS11815
• Protein ID: WP_010895177.1
• Coordinates: 2484511..2484819 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9J09_RS11780	2481439..2482200	-	762	WP_046420943.1	Bax inhibitor-1/YccA family protein	-
B9J09_RS11810	2483396..2484445	+	1050	Protein_2166	hypothetical protein	-
B9J09_RS11815	2484511..2484819	-	309	WP_010895177.1	putative addiction module antidote protein	Antitoxin
B9J09_RS11820	2484823..2485122	-	300	WP_046420946.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9J09_RS11825	2485206..2485976	+	771	WP_046420949.1	hypothetical protein	-
B9J09_RS11830	2485976..2486245	+	270	WP_046420952.1	hypothetical protein	-
B9J09_RS11835	2486564..2486940	-	377	Protein_2171	DUF596 domain-containing protein	-
B9J09_RS11840	2486945..2487337	-	393	WP_120279371.1	DUF769 domain-containing protein	-
B9J09_RS11845	2487505..2487897	-	393	WP_046420955.1	DUF596 domain-containing protein	-
B9J09_RS11850	2487907..2489010	-	1104	WP_046420959.1	DUF769 domain-containing protein	-
B9J09_RS11860	2489447..2489824	-	378	WP_046420980.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2483513..2486245	2732

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11437.25 Da
• Isoelectric Point: 10.1761

>T75596 WP_046420946.1 NZ_CP020870:c2485122-2484823 [Xylella fastidiosa subsp. pauca]
MTYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGGCVFEMREHFGPGWRMYYVQRGNFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T75596 NZ_CP020870:c2485122-2484823 [Xylella fastidiosa subsp. pauca]
ATGACCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGGAACTTTGGAGACGTGCAGCCGGTGGGTGGATGCGTGTTTGAGATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAACTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11038.60 Da
• Isoelectric Point: 4.6561

>AT75596 WP_010895177.1 NZ_CP020870:c2484819-2484511 [Xylella fastidiosa subsp. pauca]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Nucleotide

• Length: 309 bp

>AT75596 NZ_CP020870:c2484819-2484511 [Xylella fastidiosa subsp. pauca]
GTGACCATCACCAAGAAAATCAATGTCTCTGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V409