Detailed information of TA system TA075592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1168553..1169094
• Replicon: chromosome
• Accession: NZ_CP020870
• Organism: Xylella fastidiosa subsp. pauca strain De Donno

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: B9J09_RS05640
• Protein ID: WP_031336866.1
• Coordinates: 1168771..1169094 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: B9J09_RS05635
• Protein ID: WP_046419240.1
• Coordinates: 1168553..1168774 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9J09_RS05590	1164778..1164945	-	168	WP_104993205.1	phage coat protein	-
B9J09_RS05595	1165011..1165217	-	207	WP_046419249.1	hypothetical protein	-
B9J09_RS05605	1165776..1166363	-	588	WP_046419247.1	hypothetical protein	-
B9J09_RS05615	1166950..1167132	-	183	WP_046419245.1	hypothetical protein	-
B9J09_RS05620	1167136..1167402	-	267	WP_080939575.1	hypothetical protein	-
B9J09_RS05625	1167395..1167690	-	296	Protein_1015	hypothetical protein	-
B9J09_RS05630	1167836..1168264	+	429	WP_046419243.1	DUF3693 domain-containing protein	-
B9J09_RS05635	1168553..1168774	+	222	WP_046419240.1	antitoxin MazE family protein	Antitoxin
B9J09_RS05640	1168771..1169094	+	324	WP_031336866.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
B9J09_RS05645	1169352..1169684	-	333	WP_046419237.1	hypothetical protein	-
B9J09_RS05650	1169671..1170852	-	1182	WP_046419234.1	replication initiation factor domain-containing protein	-
B9J09_RS05655	1170982..1171320	+	339	Protein_1021	hypothetical protein	-
B9J09_RS05665	1171461..1172153	-	693	WP_023906504.1	7-cyano-7-deazaguanine synthase QueC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1130312..1222382	92070
	-	inside	Prophage	-	-	1129084..1172153	43069

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (9-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11771.81 Da
• Isoelectric Point: 7.9848

>T75592 WP_031336866.1 NZ_CP020870:1168771-1169094 [Xylella fastidiosa subsp. pauca]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Nucleotide

• Length: 324 bp

>T75592 NZ_CP020870:1168771-1169094 [Xylella fastidiosa subsp. pauca]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGCACTGTGTCCGGTCACGAGCGACCTGCGGAATGCGATATTTCGTGTCACCG
TTGAACCAACCGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8455.64 Da
• Isoelectric Point: 9.3510

>AT75592 WP_046419240.1 NZ_CP020870:1168553-1168774 [Xylella fastidiosa subsp. pauca]
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRRPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEGWK

Nucleotide

• Length: 222 bp

>AT75592 NZ_CP020870:1168553-1168774 [Xylella fastidiosa subsp. pauca]
ATGACATCAACTCACAGACCAGACAGCAAGATAGTTCACCATAGGGAACAGATGCGCGCAGCGGGATTGCGTCCTATGCA
GCTCTGGGTGCCGGATACGCGCAGACCGGAATTCGCTGCTGAAATTCAAAGCCAGTGCCGCGCCCTGAAAGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAGCCATGACCCATATTGAAGGTTGGAAATGA