Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 981460..982022 | Replicon | chromosome |
| Accession | NZ_CP020870 | ||
| Organism | Xylella fastidiosa subsp. pauca strain De Donno | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9PBR6 |
| Locus tag | B9J09_RS04515 | Protein ID | WP_010894527.1 |
| Coordinates | 981726..982022 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9PBR5 |
| Locus tag | B9J09_RS04510 | Protein ID | WP_010894528.1 |
| Coordinates | 981460..981738 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B9J09_RS04480 | 977560..978366 | + | 807 | WP_046420245.1 | oxidoreductase | - |
| B9J09_RS04485 | 978697..978957 | + | 261 | WP_023906425.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| B9J09_RS04490 | 978944..979225 | + | 282 | WP_060872372.1 | type II toxin-antitoxin system YafQ family toxin | - |
| B9J09_RS04500 | 979643..980677 | - | 1035 | WP_023906427.1 | serine protease | - |
| B9J09_RS12605 | 980683..980931 | - | 249 | WP_196432191.1 | transposase | - |
| B9J09_RS04510 | 981460..981738 | + | 279 | WP_010894528.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| B9J09_RS04515 | 981726..982022 | + | 297 | WP_010894527.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| B9J09_RS04520 | 982271..982411 | - | 141 | WP_196488983.1 | stabilization protein | - |
| B9J09_RS04525 | 982738..982969 | + | 232 | Protein_813 | type II toxin-antitoxin system ParD family antitoxin | - |
| B9J09_RS04530 | 982962..983258 | + | 297 | WP_046420237.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| B9J09_RS12130 | 983720..984154 | + | 435 | Protein_815 | hypothetical protein | - |
| B9J09_RS04545 | 984572..985018 | + | 447 | WP_196484560.1 | hypothetical protein | - |
| B9J09_RS04550 | 985015..985287 | + | 273 | WP_046420232.1 | hypothetical protein | - |
| B9J09_RS04555 | 985291..985599 | + | 309 | WP_010894519.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| B9J09_RS04560 | 985708..986232 | + | 525 | WP_046420230.1 | hypothetical protein | - |
| B9J09_RS04565 | 986226..986783 | + | 558 | WP_046420226.1 | recombinase family protein | - |
| B9J09_RS04570 | 986813..987022 | - | 210 | WP_060872356.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 986226..986783 | 557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11155.72 Da Isoelectric Point: 7.4670
>T75591 WP_010894527.1 NZ_CP020870:981726-982022 [Xylella fastidiosa subsp. pauca]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
Download Length: 297 bp
>T75591 NZ_CP020870:981726-982022 [Xylella fastidiosa subsp. pauca]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10772.08 Da Isoelectric Point: 5.6126
>AT75591 WP_010894528.1 NZ_CP020870:981460-981738 [Xylella fastidiosa subsp. pauca]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
Download Length: 279 bp
>AT75591 NZ_CP020870:981460-981738 [Xylella fastidiosa subsp. pauca]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0VAK4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0V821 |