Detailed information of TA system TA075590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 978697..979225
• Replicon: chromosome
• Accession: NZ_CP020870
• Organism: Xylella fastidiosa subsp. pauca strain De Donno

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B9J09_RS04490
• Protein ID: WP_060872372.1
• Coordinates: 978944..979225 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A1S0V873
• Locus tag: B9J09_RS04485
• Protein ID: WP_023906425.1
• Coordinates: 978697..978957 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9J09_RS04475	974452..977514	+	3063	WP_046420247.1	efflux RND transporter permease subunit	-
B9J09_RS04480	977560..978366	+	807	WP_046420245.1	oxidoreductase	-
B9J09_RS04485	978697..978957	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B9J09_RS04490	978944..979225	+	282	WP_060872372.1	type II toxin-antitoxin system YafQ family toxin	Toxin
B9J09_RS04500	979643..980677	-	1035	WP_023906427.1	serine protease	-
B9J09_RS12605	980683..980931	-	249	WP_196432191.1	transposase	-
B9J09_RS04510	981460..981738	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
B9J09_RS04515	981726..982022	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
B9J09_RS04520	982271..982411	-	141	WP_196488983.1	stabilization protein	-
B9J09_RS04525	982738..982969	+	232	Protein_813	type II toxin-antitoxin system ParD family antitoxin	-
B9J09_RS04530	982962..983258	+	297	WP_046420237.1	type II toxin-antitoxin system RelE/ParE family toxin	-
B9J09_RS12130	983720..984154	+	435	Protein_815	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10713.46 Da
• Isoelectric Point: 9.0869

>T75590 WP_060872372.1 NZ_CP020870:978944-979225 [Xylella fastidiosa subsp. pauca]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALVGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T75590 NZ_CP020870:978944-979225 [Xylella fastidiosa subsp. pauca]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGGTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8983.55 Da
• Isoelectric Point: 10.5972

>AT75590 WP_023906425.1 NZ_CP020870:978697-978957 [Xylella fastidiosa subsp. pauca]
MAANQLVQARIDGAIKAEATVVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT75590 NZ_CP020870:978697-978957 [Xylella fastidiosa subsp. pauca]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCGTTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V873