Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1611610..1612259 Replicon chromosome
Accession NZ_CP020857
Organism Cellulosimicrobium sp. TH-20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B8281_RS07210 Protein ID WP_021482084.1
Coordinates 1611610..1612032 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B8281_RS07215 Protein ID WP_031315781.1
Coordinates 1612029..1612259 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8281_RS07195 1607932..1609329 + 1398 WP_085387355.1 C40 family peptidase -
B8281_RS07200 1609399..1609902 - 504 WP_034655165.1 inorganic diphosphatase -
B8281_RS07205 1610163..1611575 + 1413 WP_085387356.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
B8281_RS07210 1611610..1612032 - 423 WP_021482084.1 type II toxin-antitoxin system VapC family toxin Toxin
B8281_RS07215 1612029..1612259 - 231 WP_031315781.1 antitoxin Antitoxin
B8281_RS07220 1612261..1613475 + 1215 WP_085387357.1 zinc-dependent metalloprotease -
B8281_RS07225 1613479..1614579 + 1101 WP_085387358.1 tRNA lysidine(34) synthetase TilS -
B8281_RS07230 1614585..1615139 + 555 WP_021479810.1 hypoxanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(6-42)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15032.10 Da        Isoelectric Point: 5.6065

>T75578 WP_021482084.1 NZ_CP020857:c1612032-1611610 [Cellulosimicrobium sp. TH-20]
VSTLYLLDTNVLVALLRGHGAAARPRLREAEGRVAVSTVSEMELEYGVERSQDPARNRQAVDELLSLVDVLPFDSLAAMH
AGRVRAVLAARGTPVGPYDALLAGHARSLGLVLVTNNVREFSRVPGLEVEDWLADATHGP

Download         Length: 423 bp

>T75578 NZ_CP020857:c1612032-1611610 [Cellulosimicrobium sp. TH-20]
GTGAGCACCCTCTACCTGCTGGACACGAACGTGCTCGTCGCCCTCCTCCGCGGGCACGGCGCGGCCGCGCGGCCGAGGCT
GCGCGAGGCAGAGGGGCGCGTCGCGGTCTCGACCGTGAGCGAGATGGAGCTGGAGTACGGCGTGGAGCGCTCGCAGGACC
CGGCCCGCAACCGGCAGGCGGTCGACGAGCTGCTGTCGCTCGTCGACGTGCTGCCCTTCGACAGCCTGGCGGCGATGCAC
GCCGGCAGGGTCCGGGCCGTCCTCGCGGCCCGCGGCACCCCTGTCGGCCCGTACGACGCGCTCCTCGCCGGGCACGCCCG
GTCGCTCGGGCTCGTGCTGGTGACGAACAACGTGCGCGAGTTCTCCCGCGTGCCCGGCCTGGAGGTCGAGGACTGGCTGG
CGGACGCGACGCACGGCCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8430.42 Da        Isoelectric Point: 7.0138

>AT75578 WP_031315781.1 NZ_CP020857:c1612259-1612029 [Cellulosimicrobium sp. TH-20]
VRTTVFRSNRTQAVRLPKAVALPDDVREVDVRAVGRSRVITPAGSGWDEWFEHGLRVGPGFLADRDQGTADEREAL

Download         Length: 231 bp

>AT75578 NZ_CP020857:c1612259-1612029 [Cellulosimicrobium sp. TH-20]
GTGCGCACGACGGTGTTCCGCAGCAACCGGACGCAGGCGGTCCGCCTGCCCAAGGCGGTCGCGCTGCCCGACGACGTCCG
GGAGGTGGACGTCCGGGCCGTCGGCCGGTCACGGGTCATCACCCCGGCCGGCTCCGGGTGGGACGAGTGGTTCGAGCACG
GCCTGCGCGTCGGTCCCGGCTTCCTCGCCGACCGTGACCAGGGCACCGCGGACGAGCGCGAGGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References