Detailed information of TA system TA075570

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4837995..4838652
• Replicon: chromosome
• Accession: NZ_CP020853
• Organism: Klebsiella pneumoniae strain KPN528

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: B8F96_RS23820
• Protein ID: WP_004181233.1
• Coordinates: 4837995..4838405 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: B8F96_RS23825
• Protein ID: WP_002916312.1
• Coordinates: 4838386..4838652 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B8F96_RS23800	4833995..4835728	-	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-
B8F96_RS23805	4835734..4836447	-	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
B8F96_RS23810	4836470..4837366	-	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
B8F96_RS23815	4837467..4837988	+	522	WP_004144730.1	flavodoxin FldB	-
B8F96_RS23820	4837995..4838405	-	411	WP_004181233.1	protein YgfX	Toxin
B8F96_RS23825	4838386..4838652	-	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
B8F96_RS23830	4838898..4839881	+	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
B8F96_RS23835	4840032..4840691	-	660	WP_002916317.1	hemolysin III family protein	-
B8F96_RS23840	4840855..4841166	-	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
B8F96_RS23845	4841216..4841944	+	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
B8F96_RS23850	4842063..4843496	+	1434	WP_004181234.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T75570 WP_004181233.1 NZ_CP020853:c4838405-4837995 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T75570 NZ_CP020853:c4838405-4837995 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT75570 WP_002916312.1 NZ_CP020853:c4838652-4838386 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT75570 NZ_CP020853:c4838652-4838386 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41