Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeV-yfjZ/CbtA-CbeA |
Location | 3557401..3558158 | Replicon | chromosome |
Accession | NZ_CP020847 | ||
Organism | Klebsiella variicola strain KPN1481 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | - |
Locus tag | B8O08_RS17540 | Protein ID | WP_086892949.1 |
Coordinates | 3557775..3558158 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | yfjZ | Uniprot ID | - |
Locus tag | B8O08_RS17535 | Protein ID | WP_086892948.1 |
Coordinates | 3557401..3557739 (+) | Length | 113 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
B8O08_RS17510 | 3553842..3554735 | + | 894 | WP_086892944.1 | 50S ribosome-binding GTPase | - |
B8O08_RS17515 | 3555022..3555699 | + | 678 | WP_086892945.1 | hypothetical protein | - |
B8O08_RS17520 | 3555799..3556617 | + | 819 | WP_086892946.1 | DUF945 domain-containing protein | - |
B8O08_RS17525 | 3556647..3557147 | + | 501 | WP_129557106.1 | DNA repair protein RadC | - |
B8O08_RS17530 | 3557144..3557365 | + | 222 | WP_086892947.1 | DUF987 family protein | - |
B8O08_RS17535 | 3557401..3557739 | + | 339 | WP_086892948.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
B8O08_RS17540 | 3557775..3558158 | + | 384 | WP_086892949.1 | TA system toxin CbtA family protein | Toxin |
B8O08_RS17550 | 3558701..3559954 | - | 1254 | WP_004147253.1 | glutamate-5-semialdehyde dehydrogenase | - |
B8O08_RS17555 | 3559965..3561068 | - | 1104 | WP_008805306.1 | glutamate 5-kinase | - |
B8O08_RS17560 | 3561358..3562410 | + | 1053 | WP_008805307.1 | phosphoporin PhoE | - |
B8O08_RS17565 | 3562455..3563021 | - | 567 | WP_004191825.1 | lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14373.42 Da Isoelectric Point: 9.6221
>T75546 WP_086892949.1 NZ_CP020847:3557775-3558158 [Klebsiella variicola]
MQISTAPTTEPVSSRLSPVEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDRSGF
TILEQSPFISSIDILRARRATGLMKRQGYKSISNITTGHLLQERHLR
MQISTAPTTEPVSSRLSPVEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDRSGF
TILEQSPFISSIDILRARRATGLMKRQGYKSISNITTGHLLQERHLR
Download Length: 384 bp
>T75546 NZ_CP020847:3557775-3558158 [Klebsiella variicola]
ATGCAAATTTCAACTGCACCGACCACGGAGCCTGTTTCGTCACGCCTGTCGCCTGTCGAGGTCTGGCAGATACTACTCAA
ACATCTTCTGGCACAACACTATGGTCTAACCCTTAATGACACTCCGTTCAGCGATGAAAGCACTATTCGTGAACATATCA
ATGCTGGTATCTCACTCAGTAACGCAGTGAATTTTATCGTCGAAAAATATGAGCTGGTACGTACTGACCGTAGTGGATTT
ACGATTTTGGAGCAGTCTCCCTTCATCAGCAGTATCGACATTCTTCGTGCCCGCCGGGCCACTGGATTGATGAAACGTCA
GGGTTATAAATCCATCAGCAATATCACTACTGGTCACCTTCTCCAGGAGCGACATTTACGATGA
ATGCAAATTTCAACTGCACCGACCACGGAGCCTGTTTCGTCACGCCTGTCGCCTGTCGAGGTCTGGCAGATACTACTCAA
ACATCTTCTGGCACAACACTATGGTCTAACCCTTAATGACACTCCGTTCAGCGATGAAAGCACTATTCGTGAACATATCA
ATGCTGGTATCTCACTCAGTAACGCAGTGAATTTTATCGTCGAAAAATATGAGCTGGTACGTACTGACCGTAGTGGATTT
ACGATTTTGGAGCAGTCTCCCTTCATCAGCAGTATCGACATTCTTCGTGCCCGCCGGGCCACTGGATTGATGAAACGTCA
GGGTTATAAATCCATCAGCAATATCACTACTGGTCACCTTCTCCAGGAGCGACATTTACGATGA
Antitoxin
Download Length: 113 a.a. Molecular weight: 12465.17 Da Isoelectric Point: 5.0744
>AT75546 WP_086892948.1 NZ_CP020847:3557401-3557739 [Klebsiella variicola]
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSAALDAIFPALIRDMETALLSGKLDPLEAKQ
YIYIRNGFACESDTLGSCGYVYIVIYPQSETS
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSAALDAIFPALIRDMETALLSGKLDPLEAKQ
YIYIRNGFACESDTLGSCGYVYIVIYPQSETS
Download Length: 339 bp
>AT75546 NZ_CP020847:3557401-3557739 [Klebsiella variicola]
ATGACTAAAGAACCTGTTCAGGAACACGTTTGGGGTTTACACAGTCAAACCGTTCCATCATTCAGCGCTCGGTTAGTTCA
GGAAGGTCGACGGCTGCATTTTCTGGCCGACCGTGCCACGCTTCTCGGCACATTCAGCCCGGAACAATCCGCAGCGCTGG
ATGCGATCTTCCCAGCATTAATCCGGGATATGGAAACCGCTCTGCTTAGCGGCAAACTCGACCCACTTGAGGCTAAACAA
TACATCTATATCCGCAACGGTTTCGCCTGCGAGTCAGATACGTTGGGGAGTTGCGGTTACGTTTACATCGTAATTTATCC
TCAATCAGAAACCAGCTAG
ATGACTAAAGAACCTGTTCAGGAACACGTTTGGGGTTTACACAGTCAAACCGTTCCATCATTCAGCGCTCGGTTAGTTCA
GGAAGGTCGACGGCTGCATTTTCTGGCCGACCGTGCCACGCTTCTCGGCACATTCAGCCCGGAACAATCCGCAGCGCTGG
ATGCGATCTTCCCAGCATTAATCCGGGATATGGAAACCGCTCTGCTTAGCGGCAAACTCGACCCACTTGAGGCTAAACAA
TACATCTATATCCGCAACGGTTTCGCCTGCGAGTCAGATACGTTGGGGAGTTGCGGTTACGTTTACATCGTAATTTATCC
TCAATCAGAAACCAGCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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