Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3557401..3558158 Replicon chromosome
Accession NZ_CP020847
Organism Klebsiella variicola strain KPN1481

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag B8O08_RS17540 Protein ID WP_086892949.1
Coordinates 3557775..3558158 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag B8O08_RS17535 Protein ID WP_086892948.1
Coordinates 3557401..3557739 (+) Length 113 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8O08_RS17510 3553842..3554735 + 894 WP_086892944.1 50S ribosome-binding GTPase -
B8O08_RS17515 3555022..3555699 + 678 WP_086892945.1 hypothetical protein -
B8O08_RS17520 3555799..3556617 + 819 WP_086892946.1 DUF945 domain-containing protein -
B8O08_RS17525 3556647..3557147 + 501 WP_129557106.1 DNA repair protein RadC -
B8O08_RS17530 3557144..3557365 + 222 WP_086892947.1 DUF987 family protein -
B8O08_RS17535 3557401..3557739 + 339 WP_086892948.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
B8O08_RS17540 3557775..3558158 + 384 WP_086892949.1 TA system toxin CbtA family protein Toxin
B8O08_RS17550 3558701..3559954 - 1254 WP_004147253.1 glutamate-5-semialdehyde dehydrogenase -
B8O08_RS17555 3559965..3561068 - 1104 WP_008805306.1 glutamate 5-kinase -
B8O08_RS17560 3561358..3562410 + 1053 WP_008805307.1 phosphoporin PhoE -
B8O08_RS17565 3562455..3563021 - 567 WP_004191825.1 lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-111)

Antitoxin

(9-108)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14373.42 Da        Isoelectric Point: 9.6221

>T75546 WP_086892949.1 NZ_CP020847:3557775-3558158 [Klebsiella variicola]
MQISTAPTTEPVSSRLSPVEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDRSGF
TILEQSPFISSIDILRARRATGLMKRQGYKSISNITTGHLLQERHLR

Download         Length: 384 bp

>T75546 NZ_CP020847:3557775-3558158 [Klebsiella variicola]
ATGCAAATTTCAACTGCACCGACCACGGAGCCTGTTTCGTCACGCCTGTCGCCTGTCGAGGTCTGGCAGATACTACTCAA
ACATCTTCTGGCACAACACTATGGTCTAACCCTTAATGACACTCCGTTCAGCGATGAAAGCACTATTCGTGAACATATCA
ATGCTGGTATCTCACTCAGTAACGCAGTGAATTTTATCGTCGAAAAATATGAGCTGGTACGTACTGACCGTAGTGGATTT
ACGATTTTGGAGCAGTCTCCCTTCATCAGCAGTATCGACATTCTTCGTGCCCGCCGGGCCACTGGATTGATGAAACGTCA
GGGTTATAAATCCATCAGCAATATCACTACTGGTCACCTTCTCCAGGAGCGACATTTACGATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12465.17 Da        Isoelectric Point: 5.0744

>AT75546 WP_086892948.1 NZ_CP020847:3557401-3557739 [Klebsiella variicola]
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSAALDAIFPALIRDMETALLSGKLDPLEAKQ
YIYIRNGFACESDTLGSCGYVYIVIYPQSETS

Download         Length: 339 bp

>AT75546 NZ_CP020847:3557401-3557739 [Klebsiella variicola]
ATGACTAAAGAACCTGTTCAGGAACACGTTTGGGGTTTACACAGTCAAACCGTTCCATCATTCAGCGCTCGGTTAGTTCA
GGAAGGTCGACGGCTGCATTTTCTGGCCGACCGTGCCACGCTTCTCGGCACATTCAGCCCGGAACAATCCGCAGCGCTGG
ATGCGATCTTCCCAGCATTAATCCGGGATATGGAAACCGCTCTGCTTAGCGGCAAACTCGACCCACTTGAGGCTAAACAA
TACATCTATATCCGCAACGGTTTCGCCTGCGAGTCAGATACGTTGGGGAGTTGCGGTTACGTTTACATCGTAATTTATCC
TCAATCAGAAACCAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References