Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1588119..1588776 Replicon chromosome
Accession NZ_CP020847
Organism Klebsiella variicola strain KPN1481

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B8O08_RS07790 Protein ID WP_002916310.1
Coordinates 1588119..1588529 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B8O08_RS07795 Protein ID WP_002916312.1
Coordinates 1588510..1588776 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8O08_RS07770 1584119..1585852 - 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -
B8O08_RS07775 1585858..1586571 - 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B8O08_RS07780 1586594..1587490 - 897 WP_012967247.1 site-specific tyrosine recombinase XerD -
B8O08_RS07785 1587591..1588112 + 522 WP_008806427.1 flavodoxin FldB -
B8O08_RS07790 1588119..1588529 - 411 WP_002916310.1 protein YgfX Toxin
B8O08_RS07795 1588510..1588776 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B8O08_RS07800 1589022..1590005 + 984 WP_032733797.1 tRNA-modifying protein YgfZ -
B8O08_RS07805 1590213..1590872 - 660 WP_008806429.1 hemolysin III family protein -
B8O08_RS07810 1591036..1591347 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
B8O08_RS07815 1591398..1592126 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
B8O08_RS07820 1592246..1593679 + 1434 WP_012967244.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T75541 WP_002916310.1 NZ_CP020847:c1588529-1588119 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T75541 NZ_CP020847:c1588529-1588119 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT75541 WP_002916312.1 NZ_CP020847:c1588776-1588510 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT75541 NZ_CP020847:c1588776-1588510 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References