Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5360505..5361031 Replicon chromosome
Accession NZ_CP020841
Organism Klebsiella pneumoniae strain KPN1482

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag B8O09_RS27050 Protein ID WP_000323025.1
Coordinates 5360505..5360792 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag B8O09_RS27055 Protein ID WP_000534858.1
Coordinates 5360792..5361031 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8O09_RS27020 5356126..5357388 + 1263 WP_000608644.1 IS1380-like element ISEc9 family transposase -
B8O09_RS27025 5357628..5358269 + 642 WP_000134999.1 MBL fold metallo-hydrolase -
B8O09_RS27035 5358537..5359022 + 486 WP_020277937.1 hypothetical protein -
B8O09_RS27040 5359183..5359344 - 162 WP_032426744.1 type I toxin-antitoxin system Hok family toxin -
B8O09_RS27045 5359404..5360438 + 1035 Protein_5169 IS481 family transposase -
B8O09_RS27050 5360505..5360792 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
B8O09_RS27055 5360792..5361031 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
B8O09_RS27065 5361294..5362217 - 924 WP_020277922.1 cation diffusion facilitator family transporter -
B8O09_RS27070 5362417..5362989 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
B8O09_RS27080 5363465..5364703 - 1239 WP_003030308.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / aac(6')-IIa / aadA2 / qacE / sul1 / armA / msr(E) / mph(E) / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaCMY-4 flmH / iutA / iroN 5243426..5575433 332007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T75528 WP_000323025.1 NZ_CP020841:c5360792-5360505 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T75528 NZ_CP020841:c5360792-5360505 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT75528 WP_000534858.1 NZ_CP020841:c5361031-5360792 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT75528 NZ_CP020841:c5361031-5360792 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References