Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2318106..2318763 Replicon chromosome
Accession NZ_CP020841
Organism Klebsiella pneumoniae strain KPN1482

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B8O09_RS11690 Protein ID WP_002916310.1
Coordinates 2318106..2318516 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B8O09_RS11695 Protein ID WP_002916312.1
Coordinates 2318497..2318763 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8O09_RS11670 2314106..2315839 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
B8O09_RS11675 2315845..2316558 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B8O09_RS11680 2316581..2317477 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
B8O09_RS11685 2317578..2318099 + 522 WP_002916308.1 flavodoxin FldB -
B8O09_RS11690 2318106..2318516 - 411 WP_002916310.1 protein YgfX Toxin
B8O09_RS11695 2318497..2318763 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B8O09_RS11700 2319009..2319992 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
B8O09_RS11705 2320143..2320802 - 660 WP_002916317.1 hemolysin III family protein -
B8O09_RS11710 2320966..2321277 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
B8O09_RS11715 2321327..2322055 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
B8O09_RS11720 2322174..2323607 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T75517 WP_002916310.1 NZ_CP020841:c2318516-2318106 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T75517 NZ_CP020841:c2318516-2318106 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGTTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT75517 WP_002916312.1 NZ_CP020841:c2318763-2318497 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT75517 NZ_CP020841:c2318763-2318497 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References