Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3816229..3817016 Replicon chromosome
Accession NZ_CP020835
Organism Escherichia coli strain CFSAN051542

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6I5AL91
Locus tag BCD20_RS20025 Protein ID WP_023567999.1
Coordinates 3816639..3817016 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6L5EE19
Locus tag BCD20_RS20020 Protein ID WP_023567998.1
Coordinates 3816229..3816588 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCD20_RS19980 3811580..3812293 + 714 WP_023567990.1 sporulation transcriptional regulator SpoIIID -
BCD20_RS26235 3812295..3812444 + 150 WP_001458941.1 hypothetical protein -
BCD20_RS19985 3812456..3812671 + 216 WP_023567991.1 hypothetical protein -
BCD20_RS19990 3812724..3813668 + 945 WP_077255291.1 hypothetical protein -
BCD20_RS19995 3813756..3813989 + 234 WP_023567993.1 DUF905 domain-containing protein -
BCD20_RS20000 3814100..3814921 + 822 WP_023567994.1 DUF945 domain-containing protein -
BCD20_RS20005 3815002..3815472 + 471 WP_023567995.1 antirestriction protein -
BCD20_RS20010 3815484..3815963 + 480 WP_023567996.1 DNA repair protein RadC -
BCD20_RS20015 3815984..3816205 + 222 WP_023567997.1 DUF987 domain-containing protein -
BCD20_RS20020 3816229..3816588 + 360 WP_023567998.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BCD20_RS20025 3816639..3817016 + 378 WP_023567999.1 TA system toxin CbtA family protein Toxin
BCD20_RS20030 3817013..3817504 + 492 WP_023568000.1 hypothetical protein -
BCD20_RS20035 3817531..3817734 + 204 WP_023568001.1 DUF957 domain-containing protein -
BCD20_RS20040 3817816..3818661 + 846 Protein_3675 DUF4942 domain-containing protein -
BCD20_RS20050 3818953..3820206 - 1254 WP_000893278.1 glutamate-5-semialdehyde dehydrogenase -
BCD20_RS20055 3820218..3821321 - 1104 WP_001285288.1 glutamate 5-kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14063.88 Da        Isoelectric Point: 6.7110

>T75483 WP_023567999.1 NZ_CP020835:3816639-3817016 [Escherichia coli]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKCDLVRTDRRGL
NAETQSPLLSSIDILRARKATGLMTRNDYKVVTDITNGKYREGQR

Download         Length: 378 bp

>T75483 NZ_CP020835:3816639-3817016 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATGCGATCTGGTACGAACCGACCGTCGCGGTTTG
AACGCAGAAACACAGTCCCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACCCGCAA
CGATTACAAAGTGGTGACCGACATCACCAACGGTAAATACCGCGAGGGGCAGCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13192.04 Da        Isoelectric Point: 6.3122

>AT75483 WP_023567998.1 NZ_CP020835:3816229-3816588 [Escherichia coli]
MSNEIPTVNHDITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT75483 NZ_CP020835:3816229-3816588 [Escherichia coli]
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5AL91

Antitoxin

Source ID Structure
AlphaFold DB A0A6L5EE19

References