Detailed information of TA system TA075464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 11372..11949
• Replicon: plasmid pCFSAN022990
• Accession: NZ_CP020829
• Organism: Listeria monocytogenes strain CFSAN022990

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: H1G8D6
• Locus tag: JU62_RS15105
• Protein ID: WP_003728465.1
• Coordinates: 11372..11713 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H1G8D5
• Locus tag: JU62_RS15110
• Protein ID: WP_003728464.1
• Coordinates: 11707..11949 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JU62_RS15090	7351..9753	+	2403	WP_198165251.1	hypothetical protein	-
JU62_RS15095	9923..10174	+	252	WP_049955716.1	helix-turn-helix transcriptional regulator	-
JU62_RS15100	10178..11149	+	972	WP_031641941.1	hypothetical protein	-
JU62_RS15465	11203..11346	+	144	WP_157105793.1	hypothetical protein	-
JU62_RS15105	11372..11713	-	342	WP_003728465.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
JU62_RS15110	11707..11949	-	243	WP_003728464.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JU62_RS15115	12010..12261	-	252	WP_003728463.1	hypothetical protein	-
JU62_RS15120	12392..12718	+	327	WP_031641563.1	hypothetical protein	-
JU62_RS15125	12718..13380	+	663	WP_003731676.1	DUF2786 domain-containing protein	-
JU62_RS15130	13399..13776	+	378	WP_003769263.1	DUF3850 domain-containing protein	-
JU62_RS15135	13935..14423	+	489	WP_031669356.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..67033	67033

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 16796.15 Da
• Isoelectric Point: 5.5500

>T75464 WP_003728465.1 NZ_CP020829:c11713-11372 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 342 bp

>T75464 NZ_CP020829:c11713-11372 [Listeria monocytogenes]
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Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 11939.32 Da
• Isoelectric Point: 5.5500

>AT75464 WP_003728464.1 NZ_CP020829:c11949-11707 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Nucleotide

• Length: 243 bp

>AT75464 NZ_CP020829:c11949-11707 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTT

Structures

Toxin

• AlphaFold DB: H1G8D6

Antitoxin

• AlphaFold DB: H1G8D5