Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3281..3806 Replicon plasmid pCFSAN033543
Accession NZ_CP020826
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN033543

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag ACW51_RS23825 Protein ID WP_001159863.1
Coordinates 3501..3806 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag ACW51_RS23820 Protein ID WP_000813641.1
Coordinates 3281..3499 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACW51_RS23805 1306..1601 - 296 Protein_1 cytoplasmic protein -
ACW51_RS24570 1613..2041 + 429 Protein_2 hypothetical protein -
ACW51_RS23815 2085..2606 - 522 WP_077681952.1 hypothetical protein -
ACW51_RS23820 3281..3499 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
ACW51_RS23825 3501..3806 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
ACW51_RS23830 3808..4098 + 291 WP_001266176.1 hypothetical protein -
ACW51_RS23835 4095..4616 + 522 WP_000198608.1 hypothetical protein -
ACW51_RS23840 4651..5433 + 783 WP_000082169.1 site-specific integrase -
ACW51_RS23845 5442..6155 + 714 WP_000545756.1 EAL domain-containing protein -
ACW51_RS23850 6159..6668 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
ACW51_RS23855 6662..7147 + 486 WP_000905606.1 membrane protein -
ACW51_RS23860 7424..7711 - 288 WP_071530243.1 hypothetical protein -
ACW51_RS23865 7867..8427 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59363 59363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T75463 WP_001159863.1 NZ_CP020826:3501-3806 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T75463 NZ_CP020826:3501-3806 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT75463 WP_000813641.1 NZ_CP020826:3281-3499 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT75463 NZ_CP020826:3281-3499 [Salmonella enterica subsp. enterica serovar Enteritidis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References