Detailed information of TA system TA075461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3082502..3083043
• Replicon: chromosome
• Accession: NZ_CP020822
• Organism: Tenacibaculum maritimum strain TM-KORJJ

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: B9C57_RS13480
• Protein ID: WP_136438979.1
• Coordinates: 3082741..3083043 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5S9UJX4
• Locus tag: B9C57_RS13475
• Protein ID: WP_024742610.1
• Coordinates: 3082502..3082744 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9C57_RS13445	3077561..3077968	-	408	WP_136439200.1	transposase	-
B9C57_RS13450	3078107..3078718	+	612	WP_136438973.1	hypothetical protein	-
B9C57_RS13455	3078724..3079143	+	420	WP_024742587.1	hypothetical protein	-
B9C57_RS13460	3079306..3080589	+	1284	WP_136438975.1	hypothetical protein	-
B9C57_RS13465	3080750..3081844	+	1095	WP_136438977.1	reverse transcriptase family protein	-
B9C57_RS13475	3082502..3082744	+	243	WP_024742610.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
B9C57_RS13480	3082741..3083043	+	303	WP_136438979.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9C57_RS13485	3083619..3084503	+	885	WP_136438980.1	hypothetical protein	-
B9C57_RS14770	3085052..3085198	-	147	WP_159248417.1	hypothetical protein	-
B9C57_RS13490	3085549..3086733	+	1185	WP_136438982.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12189.15 Da
• Isoelectric Point: 10.2261

>T75461 WP_136438979.1 NZ_CP020822:3082741-3083043 [Tenacibaculum maritimum]
MSKNKYRISQQAIEDLDNIWIYTLNKWSKEQADRYYDLIITEIEFIAGNFMTGKSAEQTRKNYRVTKIKSHLIFYRKMEN
DIVEIVRVLHQRMDVKKRLK

Nucleotide

• Length: 303 bp

>T75461 NZ_CP020822:3082741-3083043 [Tenacibaculum maritimum]
ATGAGTAAAAACAAATATCGCATAAGTCAACAAGCGATTGAGGATTTAGATAACATTTGGATTTATACACTTAACAAATG
GTCTAAAGAACAAGCTGATAGATATTACGACTTGATAATTACGGAGATTGAATTTATTGCTGGTAACTTTATGACAGGAA
AGTCAGCAGAACAAACTCGAAAGAATTATCGAGTGACTAAGATAAAATCACATCTGATTTTTTATAGAAAAATGGAAAAT
GATATTGTGGAAATTGTTAGAGTTTTACACCAACGAATGGATGTTAAAAAGCGACTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9320.56 Da
• Isoelectric Point: 7.4044

>AT75461 WP_024742610.1 NZ_CP020822:3082502-3082744 [Tenacibaculum maritimum]
MGKNTSISLGNHFEDFIREEVKSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVENFDPKQHLKELHRKHL

Nucleotide

• Length: 243 bp

>AT75461 NZ_CP020822:3082502-3082744 [Tenacibaculum maritimum]
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGATTTTATCAGAGAAGAAGTAAAATCTGGAAGATATGG
TTCCGTTAGCGAAGTAATTCGTTCCGCATTACGTTTATTGGAACGAGAAGAAAAAAAAGAAAGAGAACTGATTAAAGCTC
TTGAAGTTGGAGAAAATAGCGGATTTGTTGAAAATTTTGACCCAAAACAACATCTGAAAGAATTACATCGGAAACACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A5S9UJX4