Detailed information of TA system TA075438

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3835171..3835828
• Replicon: chromosome
• Accession: NZ_CP020817
• Organism: Enterobacter sp. Crenshaw

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: B7P19_RS18495
• Protein ID: WP_101744679.1
• Coordinates: 3835171..3835581 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: B7P19_RS18500
• Protein ID: WP_010435322.1
• Coordinates: 3835562..3835828 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P19_RS18475	3831164..3832897	-	1734	WP_039262981.1	single-stranded-DNA-specific exonuclease RecJ	-
B7P19_RS18480	3832903..3833616	-	714	WP_047060452.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
B7P19_RS18485	3833645..3834541	-	897	WP_023309098.1	site-specific tyrosine recombinase XerD	-
B7P19_RS18490	3834643..3835164	+	522	WP_039262979.1	flavodoxin FldB	-
B7P19_RS18495	3835171..3835581	-	411	WP_101744679.1	protein YgfX	Toxin
B7P19_RS18500	3835562..3835828	-	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
B7P19_RS18505	3836123..3837103	+	981	WP_029739202.1	tRNA-modifying protein YgfZ	-
B7P19_RS18510	3837178..3837837	-	660	WP_033146591.1	hemolysin III family protein	-
B7P19_RS18515	3838003..3838314	-	312	WP_048980550.1	N(4)-acetylcytidine aminohydrolase	-
B7P19_RS18520	3838366..3839097	+	732	WP_032660101.1	MurR/RpiR family transcriptional regulator	-
B7P19_RS18525	3839214..3840647	+	1434	WP_048980547.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16071.00 Da
• Isoelectric Point: 10.9468

>T75438 WP_101744679.1 NZ_CP020817:c3835581-3835171 [Enterobacter sp. Crenshaw]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLSQQTTQG

Nucleotide

• Length: 411 bp

>T75438 NZ_CP020817:c3835581-3835171 [Enterobacter sp. Crenshaw]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTCGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT75438 WP_010435322.1 NZ_CP020817:c3835828-3835562 [Enterobacter sp. Crenshaw]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT75438 NZ_CP020817:c3835828-3835562 [Enterobacter sp. Crenshaw]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V3PWU7