Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1049033..1049653 Replicon chromosome
Accession NZ_CP020817
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag B7P19_RS04980 Protein ID WP_008499287.1
Coordinates 1049033..1049251 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag B7P19_RS04985 Protein ID WP_008499288.1
Coordinates 1049279..1049653 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P19_RS04950 1045046..1045306 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
B7P19_RS04955 1045309..1045449 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
B7P19_RS04960 1045446..1046156 - 711 WP_048978929.1 GNAT family N-acetyltransferase -
B7P19_RS04965 1046258..1047718 + 1461 WP_048978928.1 PLP-dependent aminotransferase family protein -
B7P19_RS04970 1047690..1048157 - 468 WP_023310598.1 hypothetical protein -
B7P19_RS04975 1048276..1048827 - 552 WP_023310599.1 maltose O-acetyltransferase -
B7P19_RS04980 1049033..1049251 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
B7P19_RS04985 1049279..1049653 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
B7P19_RS04990 1050165..1053311 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
B7P19_RS04995 1053334..1054527 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T75426 WP_008499287.1 NZ_CP020817:c1049251-1049033 [Enterobacter sp. Crenshaw]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T75426 NZ_CP020817:c1049251-1049033 [Enterobacter sp. Crenshaw]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAGCTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT75426 WP_008499288.1 NZ_CP020817:c1049653-1049279 [Enterobacter sp. Crenshaw]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT75426 NZ_CP020817:c1049653-1049279 [Enterobacter sp. Crenshaw]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References