Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 257660..258256 Replicon chromosome
Accession NZ_CP020817
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name PumA Uniprot ID A0A808I9K6
Locus tag B7P19_RS01180 Protein ID WP_048979397.1
Coordinates 257954..258256 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag B7P19_RS01175 Protein ID WP_033144375.1
Coordinates 257660..257947 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P19_RS01170 256032..257663 + 1632 WP_048979396.1 Na/Pi cotransporter family protein -
B7P19_RS01175 257660..257947 - 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
B7P19_RS01180 257954..258256 - 303 WP_048979397.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7P19_RS01185 258454..259326 + 873 WP_033144377.1 23S rRNA pseudouridine(2604) synthase RluF -
B7P19_RS01190 259327..259599 - 273 WP_023309994.1 DUF3811 domain-containing protein -
B7P19_RS01195 259650..260594 - 945 WP_048979398.1 ketopantoate/pantoate/pantothenate transporter PanS -
B7P19_RS01200 260688..262037 - 1350 WP_023309996.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.17 Da        Isoelectric Point: 9.6038

>T75424 WP_048979397.1 NZ_CP020817:c258256-257954 [Enterobacter sp. Crenshaw]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRLYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T75424 NZ_CP020817:c258256-257954 [Enterobacter sp. Crenshaw]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTTGGGGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT75424 WP_033144375.1 NZ_CP020817:c257947-257660 [Enterobacter sp. Crenshaw]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp

>AT75424 NZ_CP020817:c257947-257660 [Enterobacter sp. Crenshaw]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808I9K6

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References