Detailed information of TA system TA075421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 121107..121671
• Replicon: plasmid unnamed1
• Accession: NZ_CP020810
• Organism: Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTO20_RS37220
• Protein ID: WP_087083420.1
• Coordinates: 121107..121388 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTO20_RS37225
• Protein ID: WP_087083422.1
• Coordinates: 121390..121671 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTO20_RS37190	116146..116724	+	579	Protein_114	hypothetical protein	-
BTO20_RS37195	116789..117088	-	300	WP_087072533.1	hypothetical protein	-
BTO20_RS37200	117078..117864	-	787	Protein_116	IS21-like element helper ATPase IstB	-
BTO20_RS37205	117975..119251	-	1277	Protein_117	transposase	-
BTO20_RS37210	119383..119598	-	216	WP_087083416.1	hypothetical protein	-
BTO20_RS37215	119641..120714	-	1074	WP_087083418.1	hypothetical protein	-
BTO20_RS37220	121107..121388	-	282	WP_087083420.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTO20_RS37225	121390..121671	-	282	WP_087083422.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BTO20_RS40060	121814..123019	+	1206	WP_198344622.1	helix-turn-helix transcriptional regulator	-
BTO20_RS37235	123829..125148	-	1320	WP_087083424.1	Nramp family divalent metal transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..155598	155598
	-	flank	IS/Tn	-	-	126292..126744	452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10826.26 Da
• Isoelectric Point: 11.2014

>T75421 WP_087083420.1 NZ_CP020810:c121388-121107 [Mycobacterium dioxanotrophicus]
VSGHDDSYTTRFTATARRDLDRLPPRIVSAVIEFAFGDLAREPRKAGKPLRRELAGQFSARRGPYRILYRIDEAARTVFI
HRVDHRDDAYRRL

Nucleotide

• Length: 282 bp

>T75421 NZ_CP020810:c121388-121107 [Mycobacterium dioxanotrophicus]
GTGAGCGGCCACGATGACTCCTACACGACCAGATTCACCGCGACCGCCCGCCGAGACCTCGACCGCCTACCGCCACGGAT
CGTGTCTGCGGTCATCGAGTTCGCCTTCGGTGATCTCGCGCGCGAGCCTCGTAAGGCCGGCAAACCGCTGCGGCGCGAGC
TGGCCGGACAGTTCAGCGCCCGCCGCGGCCCCTACCGCATCCTGTACCGCATCGACGAGGCTGCCCGCACCGTGTTTATC
CACCGCGTCGATCACCGCGACGACGCGTACCGGCGCCTCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10218.55 Da
• Isoelectric Point: 4.7628

>AT75421 WP_087083422.1 NZ_CP020810:c121671-121390 [Mycobacterium dioxanotrophicus]
MRIMPISRLKDKINEYVDAVSQTHDQITITKNGAPAAVLIGVDEWEEIQETLHWLSKPGVLASVAASEIDIAAGRTYGAD
EIRSAYNVPQRPS

Nucleotide

• Length: 282 bp

>AT75421 NZ_CP020810:c121671-121390 [Mycobacterium dioxanotrophicus]
ATGAGGATCATGCCGATCTCACGGCTGAAAGACAAGATCAACGAGTACGTCGACGCGGTGTCACAGACGCACGACCAGAT
CACCATCACCAAGAACGGTGCGCCAGCCGCAGTCCTTATCGGCGTCGACGAGTGGGAAGAGATTCAAGAAACCCTGCACT
GGCTCTCGAAGCCAGGAGTCCTCGCATCGGTCGCCGCGTCCGAAATCGACATCGCGGCCGGCCGCACCTACGGCGCGGAC
GAGATCCGTTCCGCCTACAACGTTCCACAACGGCCGAGCTGA