Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 6084456..6085085 Replicon chromosome
Accession NZ_CP020809
Organism Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag BTO20_RS29570 Protein ID WP_087079455.1
Coordinates 6084456..6084902 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag BTO20_RS29575 Protein ID WP_087079456.1
Coordinates 6084906..6085085 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTO20_RS29545 6080894..6081136 + 243 WP_083164979.1 hypothetical protein -
BTO20_RS29550 6081159..6082898 + 1740 WP_087079451.1 fumarate reductase (quinol) flavoprotein subunit -
BTO20_RS29555 6082905..6083657 + 753 WP_087079452.1 succinate dehydrogenase/fumarate reductase iron-sulfur subunit -
BTO20_RS29560 6083654..6084034 + 381 WP_087079453.1 fumarate reductase subunit C -
BTO20_RS29565 6084031..6084387 + 357 WP_087079454.1 fumarate reductase subunit FrdD -
BTO20_RS29570 6084456..6084902 - 447 WP_087079455.1 SRPBCC family protein Toxin
BTO20_RS29575 6084906..6085085 - 180 WP_087079456.1 antitoxin Antitoxin
BTO20_RS29580 6085157..6087532 - 2376 WP_087079457.1 cation-translocating P-type ATPase -
BTO20_RS29585 6087593..6089197 - 1605 WP_087079458.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15999.62 Da        Isoelectric Point: 9.8774

>T75420 WP_087079455.1 NZ_CP020809:c6084902-6084456 [Mycobacterium dioxanotrophicus]
MAKLSVSIDVPLPPEKAWEYASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKIKPATVDGGTGASVTFDVHLGGPALFGPIGMVVAAALKGDIQESLNKFKALYAP

Download         Length: 447 bp

>T75420 NZ_CP020809:c6084902-6084456 [Mycobacterium dioxanotrophicus]
ATGGCGAAACTTTCTGTCTCCATTGATGTTCCACTCCCGCCCGAGAAGGCATGGGAGTACGCCTCCGACCTGTCCCGGTA
CGACGAGTGGTTGAGCATTCACCGGGCGTGGCGGTCGAAGCTGCCGGAAACTCTGGAAAAGGGCACGGTCATCGACTCGA
TCGTCGAGGTCAAGGGCATGTTGAACCGCGTCAAGTGGACGCTCGTCAATTACAAGCCACCGCAGTCGCTGACCCTTAAC
GGTGACGGCCGGGGCGGGGTCAAGGTCAAGCTGATCGGAAAGATCAAGCCGGCGACGGTCGACGGCGGCACCGGCGCCAG
CGTCACGTTCGACGTGCACCTCGGTGGTCCGGCGTTGTTCGGGCCCATCGGCATGGTGGTGGCGGCGGCCCTCAAGGGGG
ACATTCAGGAGTCCCTGAACAAGTTCAAGGCCCTCTACGCCCCGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6364.07 Da        Isoelectric Point: 4.5086

>AT75420 WP_087079456.1 NZ_CP020809:c6085085-6084906 [Mycobacterium dioxanotrophicus]
MSFLDKAKDLLAQNADKVESAIDKAGDMVDEKTEGKFSGVVDKAQDAAKNAIHKDEPTQ

Download         Length: 180 bp

>AT75420 NZ_CP020809:c6085085-6084906 [Mycobacterium dioxanotrophicus]
ATGAGTTTCCTGGACAAGGCCAAGGATCTGCTGGCGCAGAACGCCGACAAGGTGGAATCCGCGATCGACAAGGCAGGCGA
CATGGTCGACGAGAAGACCGAGGGCAAGTTTTCTGGCGTTGTGGACAAGGCACAGGATGCCGCCAAGAACGCCATCCACA
AGGACGAACCGACGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References