Detailed information of TA system TA075418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3589672..3590671
• Replicon: chromosome
• Accession: NZ_CP020809
• Organism: Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: BTO20_RS17405
• Protein ID: WP_087077574.1
• Coordinates: 3589672..3590253 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: BTO20_RS17410
• Protein ID: WP_087077575.1
• Coordinates: 3590282..3590671 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTO20_RS17385	3584721..3585518	+	798	WP_087077572.1	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	-
BTO20_RS17390	3585531..3586217	+	687	WP_087082248.1	maleylpyruvate isomerase N-terminal domain-containing protein	-
BTO20_RS17395	3586232..3587740	-	1509	WP_087077573.1	PucR family transcriptional regulator	-
BTO20_RS17400	3587841..3589370	-	1530	WP_087082250.1	biotin carboxylase	-
BTO20_RS17405	3589672..3590253	-	582	WP_087077574.1	zeta toxin family protein	Toxin
BTO20_RS17410	3590282..3590671	-	390	WP_087077575.1	hypothetical protein	Antitoxin
BTO20_RS17415	3590802..3592634	+	1833	WP_087077576.1	serine/threonine protein kinase	-
BTO20_RS17420	3592660..3593961	-	1302	WP_087077577.1	TrpB-like pyridoxal phosphate-dependent enzyme	-
BTO20_RS17425	3594005..3594658	-	654	WP_157680237.1	DUF2278 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 20944.80 Da
• Isoelectric Point: 7.5692

>T75418 WP_087077574.1 NZ_CP020809:c3590253-3589672 [Mycobacterium dioxanotrophicus]
VKRLDLVVGSNGAGKSTFVELTLAPLLPNSPFVNADEIAKRRWPDDPATHSYDAARIAAQTRAALIERGESFIAETVFSH
PSKLELIDHAHQAGYGVVLHAVMIPEDLAVLRVRHRVEAGGHDVPEDKIRERYQRLWPLVATAAARSESATFYDNSTAKG
PRIVAQVAGGFAVGAPTWPKWTPAVLVSTWPGP

Nucleotide

• Length: 582 bp

>T75418 NZ_CP020809:c3590253-3589672 [Mycobacterium dioxanotrophicus]
GTGAAACGCCTCGACCTCGTCGTCGGCTCCAACGGCGCGGGGAAGTCGACCTTCGTCGAGCTCACCCTGGCACCGCTGCT
TCCGAACAGCCCCTTCGTCAACGCCGACGAGATCGCCAAGCGACGCTGGCCTGACGACCCGGCCACACATTCCTACGACG
CCGCGCGCATAGCCGCGCAAACCAGGGCCGCACTCATCGAACGGGGCGAATCCTTCATCGCCGAGACGGTGTTCTCGCAC
CCGTCGAAACTCGAACTCATCGACCACGCGCACCAAGCCGGATATGGCGTGGTGCTACACGCGGTCATGATCCCGGAGGA
CCTCGCCGTGTTGCGCGTGCGGCACCGTGTCGAGGCCGGCGGCCACGACGTGCCGGAAGACAAGATCCGCGAGCGCTACC
AACGACTTTGGCCGCTGGTCGCCACCGCTGCGGCCCGCTCGGAATCTGCGACGTTCTACGACAACAGCACCGCCAAAGGG
CCCCGCATCGTTGCCCAGGTGGCCGGCGGCTTCGCCGTCGGGGCGCCCACGTGGCCGAAATGGACACCGGCCGTGCTCGT
TTCGACCTGGCCAGGGCCGTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13607.94 Da
• Isoelectric Point: 4.6942

>AT75418 WP_087077575.1 NZ_CP020809:c3590671-3590282 [Mycobacterium dioxanotrophicus]
MTDTADRVTRFAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQQSAARRKVEAALAGDTPLRDLTSEEGVVFNAEI
SAAIEESLARGNYGAALAARGVTTVALDDNGDIVQYRPDGSTSVLVSQQ

Nucleotide

• Length: 390 bp

>AT75418 NZ_CP020809:c3590671-3590282 [Mycobacterium dioxanotrophicus]
ATGACTGACACCGCAGACCGGGTGACGCGTTTCGCCGCTGATCTGATGGACAGTGCCGCCGCAGAAGGTGCCCGTCAGAG
CCGGTCGGCCAAACAGCAGCTCGACCACTGGGCACGGGTGGGGCGGGCCGTCTCCAGCCAGCAGAGCGCAGCCCGCCGCA
AGGTGGAGGCCGCCCTGGCCGGCGACACGCCGTTGCGGGACCTGACGTCCGAGGAGGGCGTCGTGTTCAACGCCGAGATC
TCGGCGGCCATCGAAGAGAGCCTGGCACGCGGCAATTACGGCGCGGCACTGGCTGCTCGCGGGGTCACCACCGTCGCGCT
CGACGACAACGGCGACATCGTGCAGTACCGCCCCGACGGCAGCACCTCGGTGCTGGTTTCGCAGCAGTGA