Detailed information of TA system TA075417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3557639..3558186
• Replicon: chromosome
• Accession: NZ_CP020809
• Organism: Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BTO20_RS17255
• Protein ID: WP_087077558.1
• Coordinates: 3557639..3557938 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: BTO20_RS17260
• Protein ID: WP_087077559.1
• Coordinates: 3557935..3558186 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTO20_RS17230	3553491..3554141	+	651	WP_087077555.1	helix-turn-helix transcriptional regulator	-
BTO20_RS17235	3554340..3555149	-	810	WP_087077556.1	LLM class F420-dependent oxidoreductase	-
BTO20_RS17240	3555288..3556145	-	858	WP_198344421.1	polysaccharide deacetylase family protein	-
BTO20_RS17245	3556207..3556611	+	405	WP_087082236.1	MerR family transcriptional regulator	-
BTO20_RS17250	3556764..3557315	-	552	WP_087082238.1	YaeQ family protein	-
BTO20_RS17255	3557639..3557938	-	300	WP_087077558.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTO20_RS17260	3557935..3558186	-	252	WP_087077559.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BTO20_RS17265	3558350..3559444	+	1095	WP_087077560.1	GGDEF domain-containing protein	-
BTO20_RS17270	3559927..3562536	-	2610	WP_087077561.1	AAA family ATPase	-
BTO20_RS17280	3562870..3563058	-	189	WP_087077563.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3548693..3569799	21106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11357.58 Da
• Isoelectric Point: 5.5607

>T75417 WP_087077558.1 NZ_CP020809:c3557938-3557639 [Mycobacterium dioxanotrophicus]
VSRYVLSPAAQADLEQTWDYTSQRWNDDQAEAYVRVIQQAVELVAENPLIGRSCDEVRAGYRRHTAGSHTLYYRDGAGGE
LIDVVRILHKRMDVDRHLD

Nucleotide

• Length: 300 bp

>T75417 NZ_CP020809:c3557938-3557639 [Mycobacterium dioxanotrophicus]
GTGAGCCGCTATGTGCTGTCCCCTGCTGCCCAGGCCGATCTGGAGCAGACCTGGGACTACACCTCTCAACGTTGGAATGA
CGACCAGGCTGAAGCGTACGTTCGCGTGATTCAGCAGGCCGTTGAGCTTGTGGCGGAAAACCCGCTCATTGGGAGGTCCT
GCGACGAGGTTCGCGCCGGCTACCGCCGGCACACTGCGGGATCGCACACGCTCTATTACCGTGATGGCGCCGGTGGAGAG
CTGATCGACGTCGTGCGCATCCTCCACAAACGCATGGATGTGGACCGGCACCTCGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9217.14 Da
• Isoelectric Point: 6.4683

>AT75417 WP_087077559.1 NZ_CP020809:c3558186-3557935 [Mycobacterium dioxanotrophicus]
MGRNTSFSLDEHFNAFIEDEVASGRYRSASDVVRAALRLLEERETRLNALRDALVAGENSGASTPFEFDTFVSRKRASGP
HGR

Nucleotide

• Length: 252 bp

>AT75417 NZ_CP020809:c3558186-3557935 [Mycobacterium dioxanotrophicus]
ATGGGTCGAAACACCTCGTTCAGCCTGGATGAGCACTTCAACGCGTTTATCGAAGACGAGGTCGCCTCGGGACGGTATCG
GTCGGCGAGCGACGTCGTGCGCGCCGCACTCAGGCTGCTCGAGGAACGCGAGACACGCTTAAACGCCCTGCGCGACGCAT
TGGTAGCTGGTGAAAATAGCGGAGCGTCAACACCGTTCGAGTTCGACACGTTCGTGTCACGGAAACGTGCCAGCGGACCT
CACGGGCGGTGA