Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2113448..2114067 Replicon chromosome
Accession NZ_CP020809
Organism Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BTO20_RS10195 Protein ID WP_087075520.1
Coordinates 2113448..2113855 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BTO20_RS10200 Protein ID WP_087075522.1
Coordinates 2113852..2114067 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTO20_RS10175 2109923..2110135 - 213 WP_087075512.1 hypothetical protein -
BTO20_RS10180 2110286..2111464 - 1179 WP_087075514.1 restriction endonuclease subunit S -
BTO20_RS10185 2111461..2112918 - 1458 WP_087075516.1 type I restriction-modification system subunit M -
BTO20_RS10190 2113079..2113432 + 354 WP_087075518.1 DUF732 domain-containing protein -
BTO20_RS10195 2113448..2113855 - 408 WP_087075520.1 PIN domain-containing protein Toxin
BTO20_RS10200 2113852..2114067 - 216 WP_087075522.1 ribbon-helix-helix domain-containing protein Antitoxin
BTO20_RS10205 2114140..2115828 + 1689 WP_157680181.1 hypothetical protein -
BTO20_RS10210 2115910..2117754 - 1845 WP_087075527.1 AMP-binding protein -
BTO20_RS10215 2117846..2118811 - 966 WP_087075528.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-37)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14812.72 Da        Isoelectric Point: 4.2518

>T75416 WP_087075520.1 NZ_CP020809:c2113855-2113448 [Mycobacterium dioxanotrophicus]
VIVDTSALLAYFDSNEPDHQAVVEAIEGTDDRLVVSPYVLAELDYLVATRVGVDAEVAVLRELSGGAWELAAFGIPELES
AITIIRKYRDQQVGLADASNVVLAEQYRTRSIATLDRRHFDVLRPIDGGRFTVVP

Download         Length: 408 bp

>T75416 NZ_CP020809:c2113855-2113448 [Mycobacterium dioxanotrophicus]
GTGATCGTCGACACGAGCGCGCTGTTGGCCTATTTCGACTCCAATGAGCCAGACCACCAAGCCGTGGTCGAGGCCATCGA
GGGCACCGACGATCGACTCGTCGTGTCACCGTACGTTCTCGCCGAGCTCGACTACCTGGTTGCCACCCGAGTCGGAGTCG
ATGCCGAGGTGGCGGTCTTGCGGGAATTGTCGGGCGGCGCCTGGGAACTCGCCGCCTTCGGCATTCCGGAACTGGAATCG
GCCATCACCATCATCAGGAAATACCGCGATCAACAGGTCGGCCTTGCCGACGCCTCCAACGTTGTTCTGGCCGAGCAGTA
CCGCACACGCTCCATCGCGACGCTCGACCGCCGCCATTTTGACGTTCTCCGACCGATCGACGGCGGCCGATTCACCGTTG
TGCCGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7799.97 Da        Isoelectric Point: 10.6525

>AT75416 WP_087075522.1 NZ_CP020809:c2114067-2113852 [Mycobacterium dioxanotrophicus]
VEKTTIYLPDDLKAAVKRVARERGVSEAEVIRESIRAGVSINKPRPRGGLFAGPEPAARRVDELLKGFGER

Download         Length: 216 bp

>AT75416 NZ_CP020809:c2114067-2113852 [Mycobacterium dioxanotrophicus]
GTGGAGAAGACGACGATATACCTGCCTGATGACCTCAAAGCGGCAGTCAAACGCGTTGCGCGGGAGCGCGGGGTGTCAGA
GGCTGAGGTCATCCGGGAGTCCATCAGGGCGGGTGTGTCCATAAACAAGCCGCGGCCACGAGGCGGTCTCTTCGCAGGTC
CGGAGCCAGCGGCGCGCCGCGTGGACGAGCTTCTCAAAGGCTTCGGCGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References