Detailed information of TA system TA075413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/MazF-MazE
• Location: 1081238..1081812
• Replicon: chromosome
• Accession: NZ_CP020773
• Organism: Staphylococcus lutrae strain ATCC 700373

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: B5P37_RS05075
• Protein ID: WP_085237212.1
• Coordinates: 1081480..1081812 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: B5P37_RS05070
• Protein ID: WP_206168701.1
• Coordinates: 1081238..1081486 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5P37_RS05070	1081238..1081486	+	249	WP_206168701.1	AbrB family transcriptional regulator	Antitoxin
B5P37_RS05075	1081480..1081812	+	333	WP_085237212.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
B5P37_RS05080	1082095..1083093	-	999	WP_085238424.1	phosphatidylinositol-specific phospholipase C	-
B5P37_RS05085	1083484..1084398	-	915	WP_085237213.1	D-ribose ABC transporter substrate-binding protein	-
B5P37_RS05090	1084417..1085355	-	939	WP_085237214.1	ribose ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12530.67 Da
• Isoelectric Point: 10.3812

>T75413 WP_085237212.1 NZ_CP020773:1081480-1081812 [Staphylococcus lutrae]
MVKQFDIVMIDLDPTRGKEKQKYRPCVIVSNNFVNQGSPFVWALPITNRTKRFPSDIVVKTKHNSITGIIDSLQIRALDI
KARNNKIVDELDESIKSDVIKTIIAHSKII

Nucleotide

• Length: 333 bp

>T75413 NZ_CP020773:1081480-1081812 [Staphylococcus lutrae]
ATGGTAAAACAATTCGACATTGTAATGATTGATTTAGATCCTACTCGAGGTAAAGAAAAACAAAAATACCGACCGTGTGT
AATTGTAAGCAACAATTTTGTCAATCAAGGCTCGCCTTTTGTTTGGGCTTTACCTATAACTAACAGAACCAAGAGGTTTC
CTTCAGATATAGTTGTTAAAACAAAACATAATAGCATAACAGGTATCATTGATTCGCTGCAAATAAGAGCTTTAGATATT
AAAGCCAGAAATAATAAAATTGTAGATGAATTAGATGAGAGTATCAAGTCTGACGTCATCAAGACTATCATTGCACACTC
TAAAATAATTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9226.36 Da
• Isoelectric Point: 5.0893

>AT75413 WP_206168701.1 NZ_CP020773:1081238-1081486 [Staphylococcus lutrae]
MKMLSKVIKNGNSQAISLNKSILNEAGLNIGDSLNVEISEGAVKFTKREKSIINEIHDFYRNGGHYDEKEIDFGDQVGQE
LW

Nucleotide

• Length: 249 bp

>AT75413 NZ_CP020773:1081238-1081486 [Staphylococcus lutrae]
ATGAAAATGTTATCAAAAGTTATAAAAAATGGAAATAGCCAAGCAATCAGTTTAAATAAATCCATCTTAAACGAAGCAGG
TTTAAACATTGGGGATTCTTTAAATGTAGAAATAAGCGAGGGCGCAGTTAAGTTTACCAAAAGAGAAAAGTCAATTATAA
ATGAAATTCATGATTTTTATCGTAATGGGGGTCACTATGATGAAAAAGAAATTGATTTTGGCGATCAAGTAGGTCAAGAA
CTATGGTAA