Detailed information of TA system TA075412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 471194..471718
• Replicon: chromosome
• Accession: NZ_CP020773
• Organism: Staphylococcus lutrae strain ATCC 700373

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A380G4V0
• Locus tag: B5P37_RS02360
• Protein ID: WP_019169266.1
• Coordinates: 471194..471547 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: B5P37_RS02365
• Protein ID: WP_085236713.1
• Coordinates: 471548..471718 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13116.33 Da
• Isoelectric Point: 10.4439

>T75412 WP_019169266.1 NZ_CP020773:c471547-471194 [Staphylococcus lutrae]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMKEVNNAIGISLGLHMNHHK

Nucleotide

• Length: 354 bp

>T75412 NZ_CP020773:c471547-471194 [Staphylococcus lutrae]
ATGAAGCGCGGAGATGTTTATTTAGCAGATTTATCACCAGTTCAAGGGTCCGAACAAGGGGGAGTAAGACCCGTAGTCAT
TATTCAAAATGATACTGGAAATAAATATAGTCCCACAGTGATTGTTGCCGCGATTACCGGACGGATTAATAAGGCAAAAA
TACCAACGCATGTCGAAATTGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATATTACTTGAACAAATTCGGACA
GTCGATAAAAAAAGGCTGAAAGAAAAGTTGACTTTTTTGTCTGATAAGAAGATGAAAGAAGTAAACAATGCAATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6424.13 Da
• Isoelectric Point: 3.9930

>AT75412 WP_085236713.1 NZ_CP020773:c471718-471548 [Staphylococcus lutrae]
MLAFNQIRYKNIEQSLKEGYVQMADVNLSLATEAYSVECEACDCNESHLISDYKED

Nucleotide

• Length: 171 bp

>AT75412 NZ_CP020773:c471718-471548 [Staphylococcus lutrae]
ATGCTAGCATTCAATCAAATTAGGTATAAAAATATCGAACAATCATTAAAAGAAGGTTATGTTCAGATGGCAGATGTAAA
TCTCTCCCTAGCGACTGAAGCATACTCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGATATCTGACTATA
AGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A380G4V0